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View Structure Prediction Details

Protein: opa-PA
Organism: Drosophila melanogaster
Length: 609 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for opa-PA.

Description E-value Query
Range
Subject
Range
gi|76651068 - gi|76651068|ref|XP_887912.1| PREDICTED: similar to zinc finger protein 192 isoform 5 [Bos taurus]
757.0 [0..1] [609..343]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMMNAFIEPA QHHLASYGLR MSPNTTASNS NAQQQQQQQL EMTQQQQQQQ QQQQQQQQQD  60
   61 QESAAATAAA YQNSGYGHFN SYASRDFLLG RR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [93-172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAEYGVAGSA GQASAAADSM LFSGFPAQAA ELGSGFGQHP FHSHHHHHQM RMGMADAYAA  60
   61 GHPYNHHGNF PTAAVHHPVV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.39794
Match: 1g2fC
Description: TATA box-binding zinc finger, TATAZF
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [173-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHPSHHAMSA MHPAGAGAFL RYMRHQPASS ASSVKQEMQC LWIDPDQPGL VPPGGRKTCN  60
   61 KVFHSMHEIV THLTVEHVGG PECTTHACFW VGCSRNGRPF KAKYKLVNHI RVHTGEKPFA 120
  121 CPHPGCGKVF ARSENLKIHK RTHTGEKPFK CEHEGCDRRF ANSSDRKKHS HVHTSDKPYN 180
  181 CRINGCDKSY THPSSLRKHM KVHGNVDEKS PSHGYDSEGE ES

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.30103
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [395-609]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSSIITGGA QTPPSTRLDG SAGSSSGVSS LSGGSGIKSS PHSIKSEPNP MHSVHLGASS  60
   61 SGSSSTASSS ASHLLQHQQH QHQQQQQQQQ HQQQAQQQQQ LTAHPSDPKS SPALQLMAAS 120
  121 ASAYLPPPLG PPPSHHHHPH HHQAAPSPGA AAASASMLHH NHHLLYHPAA QHHPPSDWYH 180
  181 TTAPSGSAEA MNPLNHFGHH HHHHHLMHPG AATAY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.30103
Match: 2i13A
Description: No description for 2i13A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle