YRC Public Data Repository - Protein Structure Prediction

Protein:	FBpp0306925, Hus...
Organism:	Drosophila melanogaster
Length:	278 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0306925, Hus....

Description	E-value	Query Range	Subject Range
gi\|54695830, gi\|... - gi\|61365947\|gb\|AAX42789.1\| HUS1 checkpoint-like [synthetic construct], gi\|54695830\|gb\|AAV38287.1\| HU...	369.0	[0..1]	[278..1]
gi\|114613293 - gi\|114613293\|ref\|XP_519090.2\| PREDICTED: HUS1 checkpoint protein isoform 2 [Pan troglodytes] HUS1 - HUS1 checkpoint homolog (S. pombe) gi\|208966516, gi... - gi\|61356098\|gb\|AAX41208.1\| HUS1 checkpoint-like [synthetic construct], gi\|61356089\|gb\|AAX41207.1\| HU...	369.0	[0..1]	[276..1]
gi\|109066667 - gi\|109066667\|ref\|XP_001088000.1\| PREDICTED: similar to HUS1 checkpoint protein [Macaca mulatta]	368.0	[0..1]	[276..1]
gi\|149016928, gi... - gi\|157819027\|ref\|NP_001102562.1\| HUS1 checkpoint homolog [Rattus norvegicus], gi\|149016930\|gb\|EDL760...	360.0	[0..1]	[276..1]
gi\|119891181, gi... - gi\|76615586\|ref\|XP_591945.2\| PREDICTED: similar to HUS1 checkpoint protein isoform 1 [Bos taurus], g...	351.0	[0..1]	[276..1]
gi\|30060007, gi\|... - gi\|30060007\|gb\|AAP13340.1\| PCNA-like DNA checkpoint protein Hus1 [Xenopus laevis], gi\|22038051\|gb\|AA...	348.0	[0..1]	[276..1]
gi\|74189424, gi\|... - gi\|74189424\|dbj\|BAE22725.1\| unnamed protein product [Mus musculus], gi\|6680331\|ref\|NP_032342.1\| Hus1...	347.0	[0..1]	[276..1]
gi\|55742140 - ref\|NP_001006827.1\| HUS1 checkpoint homolog [Xenopus tropicalis] gi\|55742140, gi\|... - gi\|55742140\|ref\|NP_001006827.1\| HUS1 checkpoint homolog [Xenopus (Silurana) tropicalis], gi\|49904210...	344.0	[0..1]	[276..1]

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Predicted Domain #1

Region A:
Residues: [1-278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFRALMQDP LYMKEFQAIV ATLTKLAKDC VMILGSRQMH FIVNEDQSSA ASPLVWAGIT  60
   61 AEEYFPEYRM EAAHPDQEYI VLGVSSANLG RALSVLRGGG VNSCKLKLQR IQFPCISVIA 120
  121 SVLTSSSTEA REVVHDVPVT IIPGSDWSAY VVPRVPNSQL ALGLPSLRLL KSLIDKLKNI 180
  181 SPSLEFQVNV DGELNVIATS EMSTVTSRFQ KLLIRTVSGS QQEASCSVDS RKASAFFGAL 240
  241 QLPNEELTIG IDREHSIHLQ IDVRQDVVLH SILPAVCM

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.25
Match:	1iz5A
Description:	Prolifirating cell nuclear antigen (PCNA)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA polymerase activity	3.56942073327682	bayes_pls_golite062009
DNA-directed DNA polymerase activity	3.5639869830462	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.87097316781119	bayes_pls_golite062009
nucleotidyltransferase activity	2.40402506622621	bayes_pls_golite062009
DNA binding	2.04318251261279	bayes_pls_golite062009
nucleic acid binding	2.01144876655621	bayes_pls_golite062009
binding	1.89545142352738	bayes_pls_golite062009
transferase activity	1.70595878959175	bayes_pls_golite062009
catalytic activity	0.474398499157949	bayes_pls_golite062009
protein binding	0.455721709236539	bayes_pls_golite062009
structure-specific DNA binding	0.214228884882506	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: