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View Structure Prediction Details

Protein: CG14650-PA
Organism: Drosophila melanogaster
Length: 970 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG14650-PA.

Description E-value Query
Range
Subject
Range
gi|124530383, gi... - gi|124530383|ref|ZP_01701069.1| chaperone protein DnaJ [Escherichia coli B], gi|124499274|gb|EAY4676...
gi|110640228, gi... - gi|110640228|ref|YP_667956.1| chaperone protein DnaJ [Escherichia coli 536], gi|110341820|gb|ABG6805...
411.0 [0..701] [968..8]

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Predicted Domain #1
Region A:
Residues: [1-243]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATRQDDEIG GGSTESAPFR VLPHTDEVGN YLAHQQQQQQ QQQHQHQTQN YLIHQQQHGQ  60
   61 APVPLMWPPP PPHLAGPPFA PHLQQQQPHM YNEYLFNLSY SGQPGQPETY SVLPVGPGNF 120
  121 LKVYHCPDNQ VSEAGTPLFT HINMASINHH QLQHQHQAAP PTPSQPTPLY ELFATNPLTL 180
  181 PHAQQQDAQH RQPQQTQTQA PTVSQVNHSS SSANLLINNL VNNWSPNLTG GSYIQFDGEA 240
  241 NEM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [244-453]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVVLETSIAQ QPQVPNQNLQ QPEPLSQSVN TLPAASKPAK SLKMPLATAT VSPTAINKSS  60
   61 VAVPGQPEGK KRIVAEVKPM PMSYSDVLSK GTKPSAAGRD MRADNGGDYS VQSQRRPEKE 120
  121 DAYGNREMRT SKRSPLHDAK ETGSFVPGVG HAHASRGKKR SKVSQTAPLK VQQSQSLAQP 180
  181 NLQPQIKSNK LNNPEKKRPL QPKNVNSNAP 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [454-547]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFSEHKTTPV SANSSLQNHS NVLNFTPATN SSTSSRKSGS NKINSNASHS NHTGANTHAG  60
   61 SSSSSSSVNY SSNNNVSSSS AKRYSSSNLN PNNS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [548-609]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGYSYSSKRN RSNAYSSTNS PTHANSFSSN RNYELAKRII HTWWIYTLKL LTWLFYLVYD  60
   61 IV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [610-704]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLGFSMGYER ITLAYVAALA YARQLQKELK QNSGKPSIWW RSYWRRFDAR FAKNSRLAVW  60
   61 RLFYKRKPPE TTSEQFKTGR LPQTGEEAMY SLLNC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1qz2A
Description: Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.489294356963286 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [705-781]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGKDAYSILG VPPDSSQEQI RKHYKKIAVL VHPDKNKQAG AEEAFKVLQR AFELIGEPEN  60
   61 RLIYDQSIAE TLHTEKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.69897
Match: 1xblA
Description: NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.737868215447232 bayes_pls_golite062009
protein binding 0.638532996829248 bayes_pls_golite062009
unfolded protein binding 0.54782901815678 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [782-970]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WTELHDLLSQ LQTKMAEAAN TIRCSTCAQR HPRKLTERPH YAARECASCK IRHSAKDGDI  60
   61 WAETSMMGLR WKYLALMDGK VYDITEWANC QKGALSHLEP NSHMVQYRIV RGAQQQQQQQ 120
  121 QQQQQQQQQQ HHQHPQQPHH DRGVHHPGGG VSGVSEATLH EFLDNLYSGQ HPGAHNAFAG 180
  181 NARRRTRRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.154902
Match: 1nltA
Description: The crystal structure of Hsp40 Ydj1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.836371661677598 bayes_pls_golite062009
protein binding 0.608423478560768 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle