YRC Public Data Repository - Protein Structure Prediction

Protein:	eIF-4E-PE, eIF-4...
Organism:	Drosophila melanogaster
Length:	259 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eIF-4E-PE, eIF-4....

Description	E-value	Query Range	Subject Range
eIF-4E-PC - The gene Eukaryotic initiation factor 4E is referred to in FlyBase by the symbol Dmel\eIF-4E (CG4035... gi\|220951126, gi... - gi\|220959660\|gb\|ACL92373.1\| eIF-4E-PC [synthetic construct], gi\|220951126\|gb\|ACL88106.1\| eIF-4E-PC [...	317.0	[0..19]	[259..8]
gi\|125978066\|ref... - GA17897-PA [Drosophila pseudoobscura], GA28658 [Drosophila pseudoobscura pseudoobscura] gi\|54641817, gi\|... - gi\|54641817\|gb\|EAL30567.1\| GA28658 [Drosophila pseudoobscura pseudoobscura], gi\|125978066\|ref\|XP_001...	305.0	[0..1]	[259..1]
gi\|50746789 - gi\|50746789\|ref\|XP_420655.1\| PREDICTED: similar to eIF-4E [Gallus gallus]	300.0	[0..26]	[259..32]
gi\|94370433 - gi\|94370433\|ref\|XP_930840.2\| PREDICTED: similar to eIF-4E [Mus musculus]	293.0	[0..61]	[259..17]
gi\|67969074 - gi\|67969074\|dbj\|BAE00892.1\| unnamed protein product [Macaca fascicularis]	293.0	[0..65]	[259..44]
IF4E_MOUSE - Eukaryotic translation initiation factor 4E OS=Mus musculus GN=Eif4e PE=1 SV=1 IF4E_RAT - Eukaryotic translation initiation factor 4E OS=Rattus norvegicus GN=Eif4e PE=1 SV=1	293.0	[0..61]	[259..17]
gi\|147904808, gi... - gi\|7443509\|pir\|\|S69004 translation initiation factor eIF-4E, long splice form - African clawed frog,...	292.0	[0..36]	[259..2]
gi\|60830630 - gi\|60830630\|gb\|AAX36938.1\| eukaryotic translation initiation factor 4E [synthetic construct]	291.0	[0..65]	[259..21]
IF4E_RABIT - Eukaryotic translation initiation factor 4E OS=Oryctolagus cuniculus GN=EIF4E PE=1 SV=1	291.0	[0..65]	[259..21]
gi\|74001995 - gi\|74001995\|ref\|XP_544992.2\| PREDICTED: similar to Eukaryotic translation initiation factor 4E (eIF4...	290.0	[0..65]	[259..21]

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Predicted Domain #1

Region A:
Residues: [1-259]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSDFHRMKN FANPKSMFKT SAPSTEQGRP EPPTSAAAPA EAKDVKPKED PQETGEPAGN  60
   61 TATTTAPAGD DAVRTEHLYK HPLMNVWTLW YLENDRSKSW EDMQNEITSF DTVEDFWSLY 120
  121 NHIKPPSEIK LGSDYSLFKK NIRPMWEDAA NKQGGRWVIT LNKSSKTDLD NLWLDVLLCL 180
  181 IGEAFDHSDQ ICGAVINIRG KSNKISIWTA DGNNEEAALE IGHKLRDALR LGRNNSLQYQ 240
  241 LHKDTMVKQG SNVKSIYTL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	78.69897
Match:	1ipbA
Description:	Translation initiation factor eIF4e
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	12.6022960879923	bayes_pls_golite062009
RNA cap binding	9.58762092856452	bayes_pls_golite062009
translation factor activity, nucleic acid binding	7.91586572659635	bayes_pls_golite062009
translation regulator activity	7.87578736455963	bayes_pls_golite062009
binding	3.48071223822752	bayes_pls_golite062009
nucleic acid binding	3.46353214508261	bayes_pls_golite062009
RNA binding	2.50528352006389	bayes_pls_golite062009
protein binding	1.90056767012353	bayes_pls_golite062009
RNA 7-methylguanosine cap binding	0.544036568660606	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: