YRC Public Data Repository - Protein Structure Prediction

Protein:	eIF4E-3-PA
Organism:	Drosophila melanogaster
Length:	244 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eIF4E-3-PA.

Description	E-value	Query Range	Subject Range
gi\|147904808, gi... - gi\|7443509\|pir\|\|S69004 translation initiation factor eIF-4E, long splice form - African clawed frog,...	293.0	[0..17]	[244..1]
gi\|50746789 - gi\|50746789\|ref\|XP_420655.1\| PREDICTED: similar to eIF-4E [Gallus gallus]	287.0	[0..40]	[244..56]
gi\|94370433 - gi\|94370433\|ref\|XP_930840.2\| PREDICTED: similar to eIF-4E [Mus musculus]	280.0	[0..46]	[244..18]
IF4E_MOUSE - Eukaryotic translation initiation factor 4E OS=Mus musculus GN=Eif4e PE=1 SV=1 IF4E_RAT - Eukaryotic translation initiation factor 4E OS=Rattus norvegicus GN=Eif4e PE=1 SV=1	279.0	[0..46]	[244..18]
gi\|67969074 - gi\|67969074\|dbj\|BAE00892.1\| unnamed protein product [Macaca fascicularis]	279.0	[0..49]	[244..44]
gi\|62859557, gi\|... - gi\|89267996\|emb\|CAJ83126.1\| eukaryotic translation initiation factor 4E [Xenopus tropicalis], gi\|628...	279.0	[0..35]	[244..2]
gi\|125978064, gi... - gi\|54641816\|gb\|EAL30566.1\| GA19843-PA [Drosophila pseudoobscura], gi\|125978064\|ref\|XP_001353065.1\| G...	278.0	[0..48]	[243..55]

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Predicted Domain #1

Region A:
Residues: [1-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYTGYVSNG LQNAEETAWV PYGDPNDWSH GLAVYDGLEL MSGNEEELQP SLNRVMKNID  60
   61 YDLAMKHPLE HTWTLWHLEN DRTKRWAEML VDVTSFNTVE DFFSVYYFVK PPSDLKIFND 120
  121 YMVFKKNIRP MWEDDTNKNG GRWILLLDKA SRTYIDKMWH DLLLCMIGEC FQHSDEICGV 180
  181 VINVRNKANK LSLWTKDSRN VEAILSIGRQ IKELLHLGIM EIQYQVHKDA MVNHGPNVNA 240
  241 IYTL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	74.39794
Match:	1ipbA
Description:	Translation initiation factor eIF4e
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	12.6022960879923	bayes_pls_golite062009
RNA cap binding	8.70938037002519	bayes_pls_golite062009
translation factor activity, nucleic acid binding	7.91586572659635	bayes_pls_golite062009
translation regulator activity	7.87578736455963	bayes_pls_golite062009
RNA binding	4.73187299490341	bayes_pls_golite062009
nucleic acid binding	3.46353214508261	bayes_pls_golite062009
binding	2.88787215275737	bayes_pls_golite062009
RNA 7-methylguanosine cap binding	0.544036568660606	bayes_pls_golite062009
protein binding	0.153677987194444	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: