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View Structure Prediction Details

Protein: PGRP-SD-PA
Organism: Drosophila melanogaster
Length: 186 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PGRP-SD-PA.

Description E-value Query
Range
Subject
Range
gi|60688419, gi|... - gi|71896011|ref|NP_001025626.1| pglyrp1 protein [Xenopus (Silurana) tropicalis], gi|60688419|gb|AAH9...
213.0 [0..1] [184..1]
PGRP2_PIG - N-acetylmuramoyl-L-alanine amidase OS=Sus scrofa GN=PGLYRP2 PE=2 SV=1
206.0 [0..1] [186..383]
gi|62643834, gi|... - gi|62643834|ref|XP_574982.1| PREDICTED: similar to peptidoglycan recognition protein 3 [Rattus norve...
202.0 [0..18] [184..175]
gi|6651239, gi|3... - gi|6651239|gb|AAF22233.1|AF149837_1 TAGL-alpha [Mus musculus], gi|37777017|dbj|BAC99304.1| TagL-alph...
201.0 [0..1] [184..341]
gi|76621288 - gi|76621288|ref|XP_588006.2| PREDICTED: similar to N-acetylmuramoyl-L-alanine amidase precursor (Pep...
200.0 [0..1] [186..502]
gi|73986398 - gi|73986398|ref|XP_852999.1| PREDICTED: similar to N-acetylmuramoyl-L-alanine amidase precursor (Pep...
199.0 [0..1] [186..211]

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Predicted Domain #1
Region A:
Residues: [1-186]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTWIGLLIVG LTAIAVQGEV PIVTRAEWNA KPPNGAIDSM ETPLPRAVIA HTAGGACADD  60
   61 VTCSQHMQNL QNFQMSKQKF SDIGYHYLIG GNGKVYEGRS PSQRGAFAGP NNDGSLGIAF 120
  121 IGNFEERAPN KEALDAAKEL LEQAVKQAQL VEGYKLLGHR QVSATKSPGE ALYALIQQWP 180
  181 NWSEEM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.69897
Match: 1s2jA
Description: Crystal structure of the Drosophila pattern-recognition receptor PGRP-SA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidoglycan binding 9.32313496679335 bayes_pls_golite062009
peptidoglycan receptor activity 6.51660037886232 bayes_pls_golite062009
pattern recognition receptor activity 6.45255811818702 bayes_pls_golite062009
N-acetylmuramoyl-L-alanine amidase activity 5.29207604418857 bayes_pls_golite062009
pattern binding 4.06455798515101 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3.20235326428146 bayes_pls_golite062009
receptor activity 2.69681086194598 bayes_pls_golite062009
signal transducer activity 2.24692953747972 bayes_pls_golite062009
molecular transducer activity 2.24692953747972 bayes_pls_golite062009
binding 1.78736719382897 bayes_pls_golite062009
muramyl dipeptide binding 1.16811676642278 bayes_pls_golite062009
hydrolase activity 1.14017500144843 bayes_pls_golite062009
0.808368163500401 bayes_pls_golite062009
catalytic activity 0.628556091191359 bayes_pls_golite062009
0.60706691535931 bayes_pls_golite062009
protein binding 0.175384917086218 bayes_pls_golite062009

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