YRC Public Data Repository - Protein Structure Prediction

Protein:	eIF4E-4-PA
Organism:	Drosophila melanogaster
Length:	229 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eIF4E-4-PA.

Description	E-value	Query Range	Subject Range
gi\|147904808, gi... - gi\|7443509\|pir\|\|S69004 translation initiation factor eIF-4E, long splice form - African clawed frog,...	292.0	[0..3]	[229..9]
gi\|50746789 - gi\|50746789\|ref\|XP_420655.1\| PREDICTED: similar to eIF-4E [Gallus gallus]	289.0	[0..17]	[229..55]
gi\|94370433 - gi\|94370433\|ref\|XP_930840.2\| PREDICTED: similar to eIF-4E [Mus musculus]	280.0	[0..27]	[229..17]
gi\|67969074 - gi\|67969074\|dbj\|BAE00892.1\| unnamed protein product [Macaca fascicularis]	280.0	[0..31]	[229..44]
IF4E_MOUSE - Eukaryotic translation initiation factor 4E OS=Mus musculus GN=Eif4e PE=1 SV=1 IF4E_RAT - Eukaryotic translation initiation factor 4E OS=Rattus norvegicus GN=Eif4e PE=1 SV=1	280.0	[0..27]	[229..17]
gi\|125978064, gi... - gi\|54641816\|gb\|EAL30566.1\| GA19843-PA [Drosophila pseudoobscura], gi\|125978064\|ref\|XP_001353065.1\| G...	278.0	[0..33]	[228..51]
gi\|62859557, gi\|... - gi\|89267996\|emb\|CAJ83126.1\| eukaryotic translation initiation factor 4E [Xenopus tropicalis], gi\|628...	277.0	[0..17]	[229..5]

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Predicted Domain #1

Region A:
Residues: [1-229]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTTQQTEFK MMDNGTETLA DSPSSSSEDL KTLSDMDIRK PVTEIVDLRL KHPLENTWTL  60
   61 WYLENDRSKN WEDMQNEITS FDMVEDFWSL YNHIKQPSEI RVGSDYSLFK KGIQPMWEDD 120
  121 ANKFGGRWVI NMGRGSKAEL DKLWLDVLLI LIGEAFENTE EVCGAVINLR GKSNKISIWT 180
  181 ANGHNELAVM EIGLKLRDLL VLPPHQLQYQ LHKDTMCKQG SVIKAVYCV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	75.0
Match:	1ej1A
Description:	Translation initiation factor eIF4e
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	12.6022960879923	bayes_pls_golite062009
RNA cap binding	8.70938037002519	bayes_pls_golite062009
translation factor activity, nucleic acid binding	7.91586572659635	bayes_pls_golite062009
translation regulator activity	7.87578736455963	bayes_pls_golite062009
RNA binding	4.73187299490341	bayes_pls_golite062009
nucleic acid binding	3.46353214508261	bayes_pls_golite062009
binding	2.88787215275737	bayes_pls_golite062009
RNA 7-methylguanosine cap binding	0.544036568660606	bayes_pls_golite062009
protein binding	0.153677987194444	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: