YRC Public Data Repository - Protein Structure Prediction

Protein:	CG16912-PA
Organism:	Drosophila melanogaster
Length:	464 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG16912-PA.

Description	E-value	Query Range	Subject Range
SYY_SALCH - Tyrosine--tRNA ligase OS=Salmonella choleraesuis (strain SC-B67) GN=tyrS PE=3 SV=1 SYY_SALPA - Tyrosine--tRNA ligase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=tyrS PE=3 SV=1 lcl\|NC_016856.1_... - [gene=tyrS] [protein=tyrosyl-tRNA synthetase] [protein_id=YP_005237319.1] [location=1533463..1534737... SYY_SALTY - Tyrosine--tRNA ligase OS=Salmonella typhimurium GN=tyrS PE=3 SV=1 SYY_SALCH - Tyrosine--tRNA ligase OS=Salmonella choleraesuis GN=tyrS PE=3 SV=1 SYY_SALCH - Tyrosyl-tRNA synthetase OS=Salmonella choleraesuis GN=tyrS PE=3 SV=1 SYY_SALPA - Tyrosine--tRNA ligase OS=Salmonella paratyphi A GN=tyrS PE=3 SV=1 SYY_SALTY - Tyrosyl-tRNA synthetase OS=Salmonella typhimurium GN=tyrS PE=3 SV=1 SYY_SALTI - Tyrosyl-tRNA synthetase OS=Salmonella typhi GN=tyrS PE=3 SV=1 SYY_SALSV - Tyrosine--tRNA ligase OS=Salmonella schwarzengrund (strain CVM19633) GN=tyrS PE=3 SV=1 SYY_SALA4 - Tyrosine--tRNA ligase OS=Salmonella agona (strain SL483) GN=tyrS PE=3 SV=1 gi\|197239883, gi... - gi\|197261628\|ref\|ZP_03161702.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... SYY_SALPK - Tyrosine--tRNA ligase OS=Salmonella paratyphi A (strain AKU_12601) GN=tyrS PE=3 SV=1 gi\|168819199, gi... - gi\|205343665\|gb\|EDZ30429.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Wel... SYY_SALNS - Tyrosine--tRNA ligase OS=Salmonella newport (strain SL254) GN=tyrS PE=3 SV=1 SYY_SALHS - Tyrosine--tRNA ligase OS=Salmonella heidelberg (strain SL476) GN=tyrS PE=3 SV=1 gi\|194469349, gi... - gi\|194469349\|ref\|ZP_03075333.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|238913150 - gi\|238913150\|ref\|ZP_04656987.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|167994279, gi... - gi\|205327841\|gb\|EDZ14605.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar 4,[... gi\|168229823, gi... - gi\|205335458\|gb\|EDZ22222.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Ken... gi\|168235521, gi... - gi\|197291166\|gb\|EDY30519.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Sch... SYY_SALPB - Tyrosine--tRNA ligase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=tyrS PE=3 SV=1 gi\|168463140, gi... - gi\|195634532\|gb\|EDX52884.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar New... SYY_SALPB - Tyrosyl-tRNA synthetase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=tyrS PE=3 SV=1 gi\|205323596, gi... - gi\|205323596\|gb\|EDZ11435.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Sai... SYY_SALTY - Tyrosine--tRNA ligase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=tyrS PE=3 S... gi\|214000281 - gi\|214000281\|ref\|ZP_03411016.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|29141776, gi\|... - gi\|29141776\|ref\|NP_805118.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Ty... SYY_SALTI - Tyrosine--tRNA ligase OS=Salmonella typhi GN=tyrS PE=3 SV=1 gi\|213425988 - gi\|213425988\|ref\|ZP_03358738.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|213622227 - gi\|213622227\|ref\|ZP_03375010.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|16760464 - gi\|16760464\|ref\|NP_456081.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Ty... gi\|213649176 - gi\|213649176\|ref\|ZP_03379229.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|213857492 - gi\|213857492\|ref\|ZP_03384463.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... SYY_SALDC - Tyrosine--tRNA ligase OS=Salmonella dublin (strain CT_02021853) GN=tyrS PE=3 SV=1 gi\|204927912, gi... - gi\|204927912\|ref\|ZP_03219113.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... SYY_SALG2 - Tyrosine--tRNA ligase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=tyrS PE=3 SV=1 gi\|205358968, gi... - gi\|205358968\|ref\|ZP_02665896.2\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar...	410.0	[0..22]	[464..1]

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Predicted Domain #1

Region A:
Residues: [1-464]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPLRRSLLK PLQDVLRHSH RQMSQKNLLE LTDRGFFHGI FPDTAAPRMK QLFTRGQQSI  60
   61 YAGFDPTADS LHVGNLLVIM GLIHCQRAGH RPIALVGGAT GLIGDPSGRK TERNQLGETV 120
  121 IETNLKAIEQ QLRRVFENHE NCLWDSKKQK LPLAPLIIVN NADWYADLQL IDFVANMGRH 180
  181 FRMGSMLSRS SVQSRLESED GMSFTEFTYQ IFQAYDWLHL LRRHNCCFQM GGSDQTGNLM 240
  241 TGHELISRVE RKREVFGLTL PLVTTEEGDK FGKSAGNAVW LDGNKTSPFA LYQFFLRMPD 300
  301 SEVEKLLKLF TFIPLPQVEQ LMREHTKEPE KRKAQTLLAE DVTLLVHGES GLKQAERVTN 360
  361 ALYKGNVEGL AELNLSEIQQ TFQGATMVNL LTEPGMSILE LAMKAKCFPT ETDAVRIINA 420
  421 GGFYVNQKRV QNIAEVLTTG VHILRNGISL LRVGKRNFYI VRWQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	114.0
Match:	2ts1A
Description:	STRUCTURE OF TYROSYL-T/RNA SYNTHETASE REFINED AT 2.3 ANGSTROMS RESOLUTION. INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-oxygen bonds	7.16276509815667	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	7.16276509815667	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.13957775963187	bayes_pls_golite062009
tyrosine-tRNA ligase activity	6.18775771640881	bayes_pls_golite062009
ligase activity	6.11211476973434	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.63681738794687	bayes_pls_golite062009
methionine-tRNA ligase activity	2.56893064485672	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
arginine-tRNA ligase activity	1.50161401062914	bayes_pls_golite062009
tryptophan-tRNA ligase activity	1.14187887833901	bayes_pls_golite062009
cysteine-tRNA ligase activity	0.844943947059557	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.625793556381714	bayes_pls_golite062009
binding	0.485102284225571	bayes_pls_golite062009
nucleic acid binding	0.449504767632354	bayes_pls_golite062009
nucleotidyltransferase activity	0.2293846471193	bayes_pls_golite062009
glutamine-tRNA ligase activity	0.118292082006187	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: