YRC Public Data Repository - Protein Structure Prediction

Protein:	tsr-PA
Organism:	Drosophila melanogaster
Length:	148 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tsr-PA.

Description	E-value	Query Range	Subject Range
gi\|48374972 - gi\|48374972\|gb\|AAT42170.1\| putative actin depolymerizing factor [Sorghum bicolor]	179.0	[0..2]	[142..329]
gi\|95103010, gi\|... - gi\|95103010\|gb\|ABF51446.1\| actin-depolymerizing factor 1 [Bombyx mori], gi\|95102548\|gb\|ABF51212.1\| a...	170.0	[0..1]	[148..1]
gi\|91094039 - gi\|91094039\|ref\|XP_968178.1\| PREDICTED: similar to Cofilin/actin-depolymerizing factor homolog (Prot...	169.0	[0..1]	[148..1]
gi\|157103739, gi... - gi\|94469346\|gb\|ABF18522.1\| actin depolymerizing factor [Aedes aegypti], gi\|157103743\|ref\|XP_00164810...	169.0	[0..1]	[148..1]
gi\|21290884, gi\|... - gi\|31196947\|ref\|XP_307421.1\| ENSANGP00000012938 [Anopheles gambiae str. PEST], gi\|21290884\|gb\|EAA030...	168.0	[0..1]	[148..7]
gi\|54636060, gi\|... - gi\|54636060\|gb\|EAL25463.1\| GA18060-PA [Drosophila pseudoobscura], gi\|125808836\|ref\|XP_001360888.1\| G...	168.0	[0..1]	[148..1]
gi\|84028521 - gi\|84028521\|gb\|ABC49719.1\| actin depolymerizing factor-like protein [Arachis hypogaea]	168.0	[0..2]	[143..5]
ADF1_ARATH - Actin-depolymerizing factor 1 OS=Arabidopsis thaliana GN=ADF1 PE=1 SV=1 gi\|195604826 - gi\|195604826\|gb\|ACG24243.1\| hypothetical protein [Zea mays]	166.0	[0..2]	[143..5]
ADF1_PETHY - Actin-depolymerizing factor 1 OS=Petunia hybrida GN=ADF1 PE=2 SV=1	166.0	[0..2]	[143..5]
gi\|89574487, gi\|... - gi\|89574487\|gb\|ABD76374.1\| putative cofilin/actin depolymerizing factor-like protein [Acyrthosiphon ... gi\|52630915 - gi\|52630915\|gb\|AAU84921.1\| putative cofilin/actin depolymerizing factor-like [Toxoptera citricida]	165.0	[0..1]	[148..1]

Back

Predicted Domain #1

Region A:
Residues: [1-148]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASGVTVSDV CKTTYEEIKK DKKHRYVIFY IRDEKQIDVE TVADRNAEYD QFLEDIQKCG  60
   61 PGECRYGLFD FEYMHQCQGT SESSKKQKLF LMSWCPDTAK VKKKMLYSSS FDALKKSLVG 120
  121 VQKYIQATDL SEASREAVEE KLRATDRQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.69897
Match:	1f7sA
Description:	Cofilin (actin depolymerizing factor, ADF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
actin binding	7.52071741004022	bayes_pls_golite062009
cytoskeletal protein binding	6.04859625643932	bayes_pls_golite062009
actin filament binding	5.45532510538573	bayes_pls_golite062009
protein binding	2.93027234013365	bayes_pls_golite062009
binding	2.84811181543046	bayes_pls_golite062009
protein kinase activity	2.04816578082974	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.67227267699496	bayes_pls_golite062009
kinase activity	1.55883505515498	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.47782133980448	bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding	1.3406661967545	bayes_pls_golite062009
transferase activity	0.591259446255369	bayes_pls_golite062009
molecular transducer activity	0.535442033390394	bayes_pls_golite062009
signal transducer activity	0.535442033390394	bayes_pls_golite062009
structural constituent of cytoskeleton	0.482954032096802	bayes_pls_golite062009
protein tyrosine kinase activity	0.445404590790816	bayes_pls_golite062009
structural molecule activity	0.391701411061931	bayes_pls_golite062009
enzyme regulator activity	0.270847057375333	bayes_pls_golite062009
actin monomer binding	0.224304003054399	bayes_pls_golite062009
receptor binding	0.0743355952407823	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: