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View Structure Prediction Details

Protein: TBPH-PA
Organism: Drosophila melanogaster
Length: 332 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TBPH-PA.

Description E-value Query
Range
Subject
Range
gi|76633747 - gi|76633747|ref|XP_881817.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
259.0 [0..16] [331..17]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFVQVSEEE GDEPIELPAE EDGTLLLSTL QAQFPGSCGL KYRNLDTKAV RGVRSNEGRL  60
   61 FPPSVESGWG EYAYFCVFPK ENKRKSDDNL ENSTAKTKRI E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [102-262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRLRCTDLIV LGLPWKTTEE SLREYFETYG EVLMAQIKKD TKSGQSKGFG FVRFGSYDAQ  60
   61 MRVLTNRHLI DGRWCEVKVP NSKGMGHQVP CKVFVGRCTE DINSDDLREY FSKFGEVTDV 120
  121 FIPRPFRAFS FVTFLDPDVA QSLCGEDHII KGVSVHVSNA A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.0
Match: 1pgzA
Description: Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 2.96087565414382 bayes_pls_golite062009
binding 2.29041217255208 bayes_pls_golite062009
nucleic acid binding 1.91189490017911 bayes_pls_golite062009
mRNA binding 1.52245536665132 bayes_pls_golite062009
protein binding 0.0101134374085809 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [263-332]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKAEQNRNQQ VQSYNYNSAN SFGMHSYHPQ GNHMNPGRNG HHRGRQFSIL DGSERGPQQC  60
   61 QQLWWTEGAE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 2adcA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 2.96087565414382 bayes_pls_golite062009
binding 2.29041217255208 bayes_pls_golite062009
nucleic acid binding 1.91189490017911 bayes_pls_golite062009
mRNA binding 1.52245536665132 bayes_pls_golite062009
protein binding 0.0101134374085809 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle