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View Structure Prediction Details

Protein: FBpp0310589
Organism: Drosophila melanogaster
Length: 805 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0310589.

Description E-value Query
Range
Subject
Range
gi|38174461 - gi|38174461|gb|AAH60762.1| Phosphodiesterase 8A [Homo sapiens]
436.0 [0..1] [789..13]

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Predicted Domain #1
Region A:
Residues: [1-62]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRSASQGST GTSGTSSSGG NSRPGHRKSS LALALTPEDE PMDVYQRNLM DLKYPTVLPP  60
   61 NP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.30103
Match: 2ayxA
Description: No description for 2ayxA was found.

Predicted Domain #2
Region A:
Residues: [63-436]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLKALLVFHK SDSICEAITA ACQRHQLDVT LVKSKEEALD TLQKSYATAQ CYHLIIIDAR  60
   61 SSKNLDAEHI ARTIRHTHGH HLTTIIAVCK KSFFEKDDVL IALLDAGVNR CVAETTNLAM 120
  121 CSVELKQILH SIIRPHNVMS TQQALYTALH RLKEVVLITD DLLRIQYANR ATERLLNMRL 180
  181 DEIISKQLED IFVSDLSTIS EQCKNIKEFD GILTVRRKSQ EGIPMHVRVV PVACIGSAPT 240
  241 HLIFNFDVPG GQMDFIATLP QPKEAPRGSL HSVRRCSFDV RSIASDGLRR TSLAKLTSLP 300
  301 LEAPITKIIN LLSQVQENCS ADEARLIDKV LEFLKREGLY SPQMKEIRTD DPIATDLIGA 360
  361 LLTGPSVYSS RRSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.0
Match: 1w25A
Description: Response regulator PleD in complex with c-diGMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
signal transducer activity 6.27803885496668 bayes_pls_golite062009
molecular transducer activity 6.27803885496668 bayes_pls_golite062009
transcription regulator activity 4.41399633914211 bayes_pls_golite062009
adenylate cyclase activity 3.61776354332136 bayes_pls_golite062009
two-component response regulator activity 3.34935030645912 bayes_pls_golite062009
DNA binding 2.40455942568472 bayes_pls_golite062009
nucleic acid binding 2.27397473548288 bayes_pls_golite062009
binding 2.13456601528542 bayes_pls_golite062009
transcription factor activity 1.64787246557234 bayes_pls_golite062009
protein kinase activity 0.609719108152158 bayes_pls_golite062009
receptor activity 0.348089236254884 bayes_pls_golite062009
transmembrane receptor activity 0.200362612626285 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0408032640298051 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [437-805]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDSIIRTGSS TRTAAIVPAK MKSNPIIMEL LDESLSWDFD IFKLEEITDY HPLLYLGMEM  60
   61 FRRFDVFATL NIDENVCKAW LAVIEAHYRK SNTYHNSTHA ADVMQATGAF ITQLTNKDML 120
  121 VMDRMEEATA LIAAAAHDVD HPGRSSAFLC NSNDALAVLY NDLTVLENHH AAITFKLTLG 180
  181 DDKINIFKNL DKETYKSARS TIIDMILATE MTRHFEHLAK FVSVFGGEEP RDHNPQTDEE 240
  241 TSILMRRMLI KVADVSNPAR PMQFCIEWAR RIAEEYFMQT DEEKQRHLPI VMPMFDRATC 300
  301 SIPKSQIGFI EYIIQDMMHA WESFIDMPQL ITYMQINYSQ WKKYDEQGVN TLAEIMAKQP 360
  361 PVGKMANSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.522879
Match: 1oynA
Description: Catalytic domain of cyclic nucleotide phosphodiesterase pde4d
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3',5'-cyclic-nucleotide phosphodiesterase activity 4.72905094107626 bayes_pls_golite062009
cyclic-nucleotide phosphodiesterase activity 4.61245226349897 bayes_pls_golite062009
phosphoric diester hydrolase activity 3.65984874547256 bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity 3.3591603098704 bayes_pls_golite062009
3',5'-cyclic-GMP phosphodiesterase activity 2.96981753811593 bayes_pls_golite062009
hydrolase activity 1.22736412056595 bayes_pls_golite062009
catalytic activity 1.07048165010262 bayes_pls_golite062009
binding 0.994379083280533 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.511207383357891 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.432240759268351 bayes_pls_golite062009
protein binding 0.162314119157812 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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