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View Structure Prediction Details

Protein: FBpp0311714, twi...
Organism: Drosophila melanogaster
Length: 490 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0311714, twi....

Description E-value Query
Range
Subject
Range
gi|21428326 - gi|21428326|gb|AAM49823.1| AT17310p [Drosophila melanogaster]
282.0 [0..1] [490..1]

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Predicted Domain #1
Region A:
Residues: [1-243]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSARSVSPK VLLDISYKPT LPNIMELQNN VIKLIQVEQQ AYMQSGYQLQ HQQQHLHSHQ  60
   61 HHQQHHQQQH AQYAPLPSEY AAYGITELED TDYNIPSNEV LSTSSNQSAQ STSLELNNNN 120
  121 TSSNTNSSGN NPSGFDGQAS SGSSWNEHGK RARSSGDYDC QTGGSLVMQP EHKKLIHQQQ 180
  181 QQQQQHQQQI YVDYLPTTVD EVASAQSCPG VQSTCTSPQS HFDFPDEELP EHKAQVFLPL 240
  241 YNN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [244-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQQSQQLQQ QQPHQQSHAQ MHFQNAYRQS FEGYEPANSL NGSAYSSSDR DDMEYARHNA  60
   61 LSSVSDLNGG VMSPACLADD GSAGSLLDGS DAGGKAFRKP RRRLKRKP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [352-490]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKTEETDEFS NQRVMANVRE RQRTQSLNDA FKSLQQIIPT LPSDKLSKIQ TLKLATRYID  60
   61 FLCRMLSSSD ISLLKALEAQ GSPSAYGSAS SLLSAAANGA EADLKCLRKA NGAPIIPPEK 120
  121 LSYLFGVWRM EGDAQHQKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1mdyA
Description: Myod B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
promoter binding 0.8576109846276 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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