YRC Public Data Repository - Protein Structure Prediction

Protein:	Mes4-PA, Mes4-PB
Organism:	Drosophila melanogaster
Length:	155 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Mes4-PA, Mes4-PB.

Description	E-value	Query Range	Subject Range
gi\|74004226 - gi\|74004226\|ref\|XP_854088.1\| PREDICTED: similar to histone 1, H2ai (predicted) [Canis familiaris]	134.0	[0..4]	[146..18]
gi\|50728592 - gi\|50728592\|ref\|XP_416193.1\| PREDICTED: similar to histone protein Hist2h3c1 [Gallus gallus]	128.0	[0..13]	[145..614]
gi\|88943485 - gi\|88943485\|ref\|XP_497711.2\| PREDICTED: similar to H3 histone, family 2 isoform 2 [Homo sapiens]	128.0	[0..17]	[145..43]
gi\|159122333 - gi\|159122333\|gb\|EDP47454.1\| CCAAT-binding factor complex subunit HapE [Aspergillus fumigatus A1163] gi\|66845174, gi\|... - gi\|70984052\|ref\|XP_747547.1\| CCAAT-binding factor complex subunit HapE [Aspergillus fumigatus Af293]...	127.0	[0..15]	[154..14]
gi\|2583171 - gi\|2583171\|gb\|AAC15237.1\| CCAAT-binding transcription factor subunit AAB-1 [Neurospora crassa]	127.0	[0..10]	[154..11]
gi\|76620701 - gi\|76620701\|ref\|XP_596506.2\| PREDICTED: similar to histone 1, H2ai (predicted) [Bos taurus]	126.0	[0..14]	[145..55]
gi\|85084036 - gi\|85084036\|ref\|XP_957240.1\| hypothetical protein ( (AF026550) CCAAT-binding transcription factor su... gi\|32403178, gi\|... - gi\|32403178\|ref\|XP_322202.1\| hypothetical protein ( (AF026550) CCAAT-binding transcription factor su...	126.0	[0..10]	[154..11]
gi\|116057937 - gi\|116057937\|emb\|CAL54140.1\| Histones H3 and H4 (ISS) [Ostreococcus tauri]	126.0	[0..19]	[145..37]

Back

Predicted Domain #1

Region A:
Residues: [1-155]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASEELFEAE FSEEQDLEHQ QAMETEEAEL AETEEPLEIT EESPDNPEAE STTEQLTEKP  60
   61 VTNGNKAPAD NEAKMTQLPL ARIRNIMKLD PDLHMANNEA VFIVAKAVEL FIASLSRESY 120
  121 TYTAQSKKKT IQKRDVDMAI SAVDSLLFLD GAMNF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.69897
Match:	1u35A
Description:	Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA-directed DNA polymerase activity	7.30463919195401	bayes_pls_golite062009
DNA polymerase activity	7.25909396656216	bayes_pls_golite062009
nucleotidyltransferase activity	4.91761894051618	bayes_pls_golite062009
DNA binding	3.33590750206299	bayes_pls_golite062009
nucleic acid binding	3.33150991098513	bayes_pls_golite062009
transcription regulator activity	2.74104602193943	bayes_pls_golite062009
binding	2.68226682911828	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.18081531032351	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.71814239259767	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.71244156762178	bayes_pls_golite062009
transferase activity	1.4922191078713	bayes_pls_golite062009
transcription factor activity	1.43258372806556	bayes_pls_golite062009
transcription activator activity	0.56890094816403	bayes_pls_golite062009
transcription factor binding	0.48055497002898	bayes_pls_golite062009
protein binding	0.38229791767081	bayes_pls_golite062009
transcription cofactor activity	0.36684586697198	bayes_pls_golite062009
transcription repressor activity	0.0502944474168801	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: