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View Structure Prediction Details

Protein: FBpp0309235, eIF...
Organism: Drosophila melanogaster
Length: 910 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0309235, eIF....

Description E-value Query
Range
Subject
Range
gi|109459395, gi... - gi|109462864|ref|XP_001079906.1| PREDICTED: similar to eukaryotic translation initiation factor 3, s...
1011.0 [0..1] [881..108]

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Predicted Domain #1
Region A:
Residues: [1-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRFFANGSE SESESSEEEI QATNFNKASA FQFSDDEEEV KRVVRSTKEK RYENLTSIIK  60
   61 TIRNHKKIKD IPNTLSSFED LTRAYQKALP VISKEENGIT PRFYIRCLAE LEDFINEVWE 120
  121 DREGRKNLSK NNSKSLGTLR QKVRKYIKDF EDDLSRFREA PDQESEAEDE VVALESDGGD 180
  181 AGDDSDAGVK PTEAVPKAVK SAPAKAAPAD DDDSDDSIDW DSDSESETES SDDENQYQNM 240
  241 RERFLKRTTE KEEKDDDKRK DKRKEQKTKI RKRAEDDEDG EWETVVKGHV V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [292-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKPKMFEKDA EIDVPLVLAK LLEIMSARGK KRTDRRLQID LLFELRDISD QHNLGTAVSV  60
   61 KIHFNIISAI YDYN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #3
Region A:
Residues: [366-567]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKISEPMKLE HWALLLEVMQ SMMKLLLANA DIIMSESVAE EHEEYATSPF YVRGCPLAAV  60
   61 ERLDDEFVKL LKECDPHSND YVSRLKDEVN VVKTIELVLQ YFERSGTNNE RCRIYLRKIE 120
  121 HLYYKFDPEV LKKKRGELPA TTSTSVDVMD KLCKFIYAKD DTDRIRTRAI LAHIYHHAMH 180
  181 DNWFQARDLV LMSHLQDNID AA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [568-686]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPATRILYNR MMANLGLCAF RQGNVKDAHH CLVDLMVTGK PKELLAQGLL PQRQHERSAE  60
   61 QEKIEKQRQM PFHMHINLEL LECVYLVSAM LLEIPYIAAH EFDARRRMIS KTFYQQLRS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [687-843]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SERQSLVGPP ESMREHVVAA AKAMRCGNWQ ACANFIVNKK MNTKVWDLFY ESDRVREMLT  60
   61 KFIKEESLRT YLFTYSNVYT SISIPSLAQM YELPVPKVHS IISKMIINEE LMASLDDPSE 120
  121 TVGMHRSEPS RLQALAMQFV DKVTNLVDVN EKVFDMK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.53
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.85334044543318 bayes_pls_golite062009
nucleic acid binding 2.8293727459515 bayes_pls_golite062009
DNA binding 2.66906990480864 bayes_pls_golite062009
binding 2.14387047687719 bayes_pls_golite062009
transcription factor activity 1.97506348695089 bayes_pls_golite062009
structural constituent of ribosome 0.764002516817766 bayes_pls_golite062009
structural molecule activity 0.756450227832198 bayes_pls_golite062009
sequence-specific DNA binding 0.665091289283954 bayes_pls_golite062009
transcription activator activity 0.542530812773621 bayes_pls_golite062009
transcription repressor activity 0.423955395883599 bayes_pls_golite062009
protein binding 0.0300097532511948 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [844-910]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGNFFQRGNM GNRGDRGYNR NQNNQGGNWL GQRRDRNNRN RNQRGHHKNN QDRQQQQQQQ  60
   61 VQTIDEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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