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View Structure Prediction Details

Protein: POSH-PA
Organism: Drosophila melanogaster
Length: 838 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POSH-PA.

Description E-value Query
Range
Subject
Range
gi|109510071 - gi|109510071|ref|XP_001054057.1| PREDICTED: similar to SH3 domain containing ring finger 1 isoform 1...
266.0 [0..1] [835..1]

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Predicted Domain #1
Region A:
Residues: [1-130]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEHTLNDLL ECSVCLERLD TTSKVLPCQH TFCRKCLQDI VASQHKLRCP ECRILVSCKI  60
   61 DELPPNVLLM RILEGMKQNA AAGKGEEKGE ETETQPERAK PQPPAESVAP PDNQLLQLQS 120
  121 HQQSHQPARH 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.09691
Match: 2egpA
Description: No description for 2egpA was found.

Predicted Domain #2
Region A:
Residues: [131-479]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQRRFLLPHA YALFDFASGE ATDLKFKKGD LILIKHRIDN NWFVGQANGQ EGTFPINYVK  60
   61 VSVPLPMPQC IAMYDFKMGP NDEEGCLEFK KSTVIQVMRR VDHNWAEGRI GQTIGIFPIA 120
  121 FVELNAAAKK LLDSGLHTHP FCHPPKQQGQ RALPPVPVID PTVVTESSSG SSNSTPGSSN 180
  181 SSSTSSSNNC SPNHQISLPN TPQHVVASGS ASVRFRDKGA KEKRHSLNAL LGGGAPLSLL 240
  241 QTNRHSAEIL SLPHELSRLE VSSSTALKPT SAPQTSRVLK TTVQQQMQPN LPWGYLALFP 300
  301 YKPRQTDELE LKKGCVYIVT ERCVDGWFKG KNWLDITGVF PGNYLTPLR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.33
Match: 1griA
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.52774929405779 bayes_pls_golite062009
protein binding 1.28384864078887 bayes_pls_golite062009
cytoskeletal protein binding 0.890565712002955 bayes_pls_golite062009
actin binding 0.00539984922981329 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [480-612]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARDQQQLMHQ WKYVPQNADA QMAQVQQHPV APDVRLNNML SMQPPDLPPR QQQATATTTS  60
   61 CSVWSKPVEA LFSRKSEPKP ETATASTTSS SSSGAVGLMR RLTHMKTRSK SPGASLQQVP 120
  121 KEAISTNVEF TTN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [613-838]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSAKLHPVHV RSGSCPSQLQ HSQPLNETPA AKTAAQQQQF LPKQLPSAST NSVSYGSQRV  60
   61 KGSKERPHLI CARQSLDAAT FRSMYNNAAS PPPPTTSVAP AVYAGGQQQV IPGGGAQSQL 120
  121 HANMIIAPSH RKSHSLDASH VLSPSSNMIT EAAIKASATT KSPYCTRESR FRCIVPYPPN 180
  181 SDIELELHLG DIIYVQRKQK NGWYKGTHAR THKTGLFPAS FVEPDC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.0
Match: 1mv3A
Description: NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC
Matching Structure (courtesy of the PDB):

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