YRC Public Data Repository - Protein Structure Prediction

Protein:	Prosalpha5-PA, P...
Organism:	Drosophila melanogaster
Length:	244 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Prosalpha5-PA, P....

Description	E-value	Query Range	Subject Range
gi\|1498589 - gi\|1498589\|gb\|AAB93421.1\| 20S proteasome alpha subunit PSMA5 [Drosophila melanogaster]	283.0	[0..1]	[244..1]
gi\|218186097 - gi\|218186097\|gb\|EEC68524.1\| hypothetical protein OsI_36813 [Oryza sativa Indica Group] PSA5_ORYSJ - Proteasome subunit alpha type-5 OS=Oryza sativa subsp. japonica GN=PAE1 PE=2 SV=1 PSA5_ORYSA - Proteasome subunit alpha type 5 (EC 3.4.25.1) (20S proteasome alpha subunit E) (20S proteasome subun...	274.0	[0..1]	[243..1]
gi\|195150345, gi... - gi\|195150345\|ref\|XP_002016115.1\| GL11421 [Drosophila persimilis], gi\|194109962\|gb\|EDW32005.1\| GL1142... gi\|54635733\|gb\|E... - GA10654-PA [Drosophila pseudoobscura], GA10654 [Drosophila pseudoobscura pseudoobscura] gi\|54635733, gi\|... - gi\|54635733\|gb\|EAL25136.1\| GA10654 [Drosophila pseudoobscura pseudoobscura], gi\|125807908\|ref\|XP_001...	273.0	[0..1]	[244..1]
PSA5_SCHPO - Probable proteasome subunit alpha type-5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=p... SPAC323.02c - 20S proteasome component alpha 5	272.0	[0..1]	[238..1]
PSA5A_ARATH - Proteasome subunit alpha type-5-A OS=Arabidopsis thaliana GN=PAE1 PE=1 SV=1	271.0	[0..1]	[243..1]
gi\|16943777 - gi\|16943777\|emb\|CAD10778.1\| 20S proteasome subunit alpha V [Physcomitrella patens]	270.0	[0..1]	[243..1]
PSA5_SOYBN - Proteasome subunit alpha type-5 OS=Glycine max GN=PAE1 PE=2 SV=1	269.0	[0..1]	[243..1]
gi\|31211921, gi\|... - gi\|31211921\|ref\|XP_314945.1\| AGAP008816-PA [Anopheles gambiae str. PEST], gi\|30176407\|gb\|EAA10150.2\|... AGAP008816-PA - 20S proteasome subunit alpha 5\|protein_coding\|3R:18292958:18293846:1\|gene:AGAP008816	268.0	[0..1]	[244..1]
gi\|157105494, gi... - gi\|94469194\|gb\|ABF18446.1\| 20S proteasome regulatory subunit alpha type PSMA5/PUP2 [Aedes aegypti],...	268.0	[0..1]	[244..1]

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Predicted Domain #1

Region A:
Residues: [1-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLTRSEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGI CTPEGVVLAV EKRITSPLMV  60
   61 PSTVEKIVEV DKHIGCATSG LMADARTLIE RARVECQNHW FVYNERMSIE SCAQAVSTLA 120
  121 IQFGDSGDSD GAAAMSRPFG VAILFAGIEA GQPQLWHMDP SGTFVRHGAK AIGSGSEGAQ 180
  181 QNLQDLFRPD LTLDEAIDIS LNTLKQVMEE KLNSTNVEVM TMTKEREFYM FTKEEVEQHI 240
  241 KNIA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.69897
Match:	1iruE
Description:	Proteasome alpha subunit (non-catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
binding	1.75265921676176	bayes_pls_golite062009
nucleic acid binding	1.39216781236247	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: