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View Structure Prediction Details

Protein: unc-5-PA, FBpp03...
Organism: Drosophila melanogaster
Length: 1072 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-5-PA, FBpp03....

Description E-value Query
Range
Subject
Range
gi|8248423 - gi|8248423|gb|AAF74193.1|AF247762_1 Netrin receptor DUnc5 [Drosophila melanogaster]
720.0 [0..1] [1072..1]

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Predicted Domain #1
Region A:
Residues: [1-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVINKAGNV IALLLVKLQL ILLFTLSVSG ELPQLDYGSL SASLEEDAID PLTAMAPFAN  60
   61 SLVTEESAQH KNNAELLGNS SEDENVRPQQ GSSSSGLGSS GAAGGSGILL EEFNSGKLSP 120
  121 GEASNTLPIF LIEPESVFVV KNRPAVLKCK ASHSLQVIFK CSGSSQPPPS THETHVDPHT 180
  181 GVNMEEVTAT IHRDLVDEFF GDGPFKCECH AWSSRGVVKS QAATVHIAYI RKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.0
Match: 2v9qA
Description: No description for 2v9qA was found.

Predicted Domain #2
Region A:
Residues: [234-602]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNQSPTSLRL ELGSRAELRC EPPGGFPEPK LTWHKNNAVI TADSEPGITV SAGTLIFRQV  60
   61 ALQHMANYSC SAENIAGRRV SDSAVLIVYV NGGWSTWSPW RECKCAGKPS QGRKRSRTCN 120
  121 NPMPLNGGAQ CPGPQIQKSA DCAACPEDTQ IVSPDGFDIS SSKRMARWSA WSDWSICSAE 180
  181 CIQVRRRKCL TQGQTQISSE AEEAGDLLLG APGVGMAALI AAAGVGAVGS PSEATGSSSD 240
  241 IIPGYGKSLC AGKDIQTAEC RGEQCQIGKD DFDWTLYLGL AFITAVCFAF GTALICCARR 300
  301 GIRTNPHYNM ARSVMDADYM PGVVEKKEMR MHIEASNMGY DYVNPGHRYL PGEHIMGMGI 360
  361 GCGGVTEHH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 1w0rA
Description: Solution structure of dimeric form of properdin by X-ray solution scattering and analytical ultracentrifugation
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [603-819]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDVPNLSANY TNPIDHLSVD YLSETGESST ADTSNSTFDM NGKLSILNAS KSSTYEMLGS  60
   61 AGGQLRLYGG ELLLFVPEHA IGKHVKKHVS LLLLSDECSR VSCATESSIL CSSVVHSAPR 120
  121 NYSFVKPVIL KIPHCLVAPE QWHVHIYHAD SEHDELSVNW RRAVSVGEET INTPMFVQLE 180
  181 ATHVFIMTEQ LGHFTVVAEP RIQQPSIKMK LLAFSQH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [820-936]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPPSNANCSL RIYVVKDFPN SRDICANVEA KLGGSFLGES QVFAFTLNSR NLNIRVRSAD  60
   61 VEAAAPYEHA IPYQHILSNN SILHCEFSLR RQDQNSLCVD FGQGSEDDYY TFNIPAH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [937-1072]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SMSGSAEELA STTNTTISID RQGNYVNESC VMDFVQLPHA TKRLICGALD PPRADERDWR  60
   61 LLAKKLNTDR YIAYFATKAS PTEQILNLWE CRANSSPGSS SNSVSHTIMA LLLTLKEMGR 120
  121 QDVLDIIVET IGPLWI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.522879
Match: 1wmgA
Description: Crystal structure of the UNC5H2 death domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.81925838257497 bayes_pls_golite062009
protein binding 2.45473206123776 bayes_pls_golite062009
transmembrane receptor activity 1.79234496253717 bayes_pls_golite062009
receptor activity 1.73411211759611 bayes_pls_golite062009
signal transducer activity 1.48908901984354 bayes_pls_golite062009
molecular transducer activity 1.48908901984354 bayes_pls_golite062009
netrin receptor activity 1.19822565953592 bayes_pls_golite062009
protein domain specific binding 0.8302342819454 bayes_pls_golite062009
cytokine binding 0.34960245851041 bayes_pls_golite062009
death receptor activity 0.15603114432983 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle