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View Structure Prediction Details

Protein: Sox15-PA
Organism: Drosophila melanogaster
Length: 784 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Sox15-PA.

Description E-value Query
Range
Subject
Range
gi|66571104 - gi|66571104|gb|AAY51517.1| IP09065p [Drosophila melanogaster]
290.0 [0..1] [784..1]

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Predicted Domain #1
Region A:
Residues: [1-134]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPSYDHEHP HHLLTNYNSK KYPHVSRTPE YSHSTGSDYP EHGGYLTDGR LMHESNSDAG  60
   61 IYHVRQGSEH SSPSLHSPAI QSSGYENEHL NEAVLAAHSH SHSPMPMVSS AYVGGGTASG 120
  121 SLINSNIPLL GGGG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [135-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSVLNKFLSH PHAGMVGGGT GQMEDCTSHS PIEAASMWSY DYKGDLCAPN CGYLERHKPL  60
   61 PADLKYRPGG TQSKSAKESR IRRPMNAFMV WAKIERKKLA DENPDLHNAD LSKMLGKKWR 120
  121 SLTPQDRRPY VEEAERLRVI HMTEHPNYKY RPRRRKQSKL RAMQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1o4xB
Description: TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.15324651287773 bayes_pls_golite062009
transcription regulator activity 4.9607192917135 bayes_pls_golite062009
nucleic acid binding 4.70730250099648 bayes_pls_golite062009
transcription factor activity 3.82658263870186 bayes_pls_golite062009
binding 3.6211482127468 bayes_pls_golite062009
sequence-specific DNA binding 2.96229555092695 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.84606709725198 bayes_pls_golite062009
transcription activator activity 1.62744929149746 bayes_pls_golite062009
transcription repressor activity 1.53825678633232 bayes_pls_golite062009
protein binding 1.131658134984 bayes_pls_golite062009
transcription factor binding 1.10315330167937 bayes_pls_golite062009
DNA bending activity 0.87985209274756 bayes_pls_golite062009
chromatin binding 0.830960835937769 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [299-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGGKEQSESS PNPGTGGSKS NPKLATPPLA TASSSYTTPT DESTCNSTNQ NHGQSTPGGL  60
   61 YEQPLKPTYS PSSVDCYSNA DSTEQIESLA AN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.22
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [391-490]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPPALLNESS PTGGGYDNSL LLKKLTKPSP SRAAKSRQEK LAKSEEKNKG SQSQGQSQQG  60
   61 IYAATYPLAP TSVAVVAARG MYVTCNNRGL LDHGHSVKGT 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [491-614]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FYPPVSVSED DNSTSMRNSI SALQQHCNVV TSTPSSSGGT MPTSEMSSYT VSMADNCGNL  60
   61 RLSMNELSGN EYLPSANAYG MQYEDFLRYQ SNDMDYSTSA VEHKETTSDS ASGQKCLKYP 120
  121 DTNQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.30103
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [615-784]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYDDYEAEAY SNAMLPATAA SYYTQLPYPP TSLAAFPLQL AVPFQQTTSG AYGAQPIQSG  60
   61 YLHYGNYGGY EGMAQSQPQN QAPVHHQQAS HSAPPSLSVP PNQTVTSNSA AISMQQHHHH 120
  121 HFGPAPGMVG VGVGVGVGVG VGEMLFEQQQ RKDDEISNIL AGVRKTCYSN 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.0
Match: 1c82A
Description: Hyaluronate lyase
Matching Structure (courtesy of the PDB):

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