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View Structure Prediction Details

Protein: cg-PB
Organism: Drosophila melanogaster
Length: 772 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cg-PB.

Description E-value Query
Range
Subject
Range
gi|114671709 - gi|114671709|ref|XP_511785.2| PREDICTED: zinc finger protein 624 [Pan troglodytes]
923.0 [0..1] [770..413]

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Predicted Domain #1
Region A:
Residues: [1-203]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCAAQNPPPF GYTWGFADNG NRAAESVLEI SPNINYTVSG ESMPYLLSTD GSLAVQKDVK  60
   61 GLTAGGKNNV VRRMFVVNDP SFPPGTQRVI TAGGASTVVK KQDNNQQVLS LDKNYLLVDP 120
  121 ATAAAAAAAA GGDSGLAHHH TLTNGSIVDA KTGQTVLTAG SAAAKSHFSS IGALHLTQEE 180
  181 CNEILIKRAI AAGHHQTHTI TAA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [204-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGSHHHASGG TPSDILPGIS VQVQKVIQGL EDNEDSQGEA PNLKLEPGTL ELSPKTELQE  60
   61 SMHFSETDAT IKKERPYSCD ECGKSFLLKH HLTTHARVHT GERPHICTHC GKSFAHKHCL 120
  121 NTHLLLHSTE RPYQCQECKK SFTLKHHLLT HSRVHSRERP FVCQECGRAF PLKRHLVTHS 180
  181 KFHAGERPYV CEECGESFAQ ENHLIMHSRF HGSLNPFVCA ECGASFPRKF QLVNHGRIHG 240
  241 KI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.0
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [446-618]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHSCTVCGKE FLQKRTLVSH MRRVHTGEQA HPCVSCGEGF LTKAELHQHV RTAHNGVNPN  60
   61 TSSATIIANQ QLQQAHHHQA GQQTHPQTIT VVSNPGNSTL LTVSTTDANG VARPQFVCRE 120
  121 CGSAFNSREA LALHLRLHTG DKSLMTDLCA LTAALPGHFL STASLNPGTV VTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.69897
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
structure-specific DNA binding 1.48624530884061 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
double-stranded DNA binding 1.18599503594288 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [619-701]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPNLVGQSPV PVQIISSTGQ VMSQTTLVQA ANSTHPQAVV TAVPTMPVHG QQQHLQHVAQ  60
   61 QQQQQQQQQQ QQQQHVVSVA PAN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [702-772]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPKSHFCASC GKGFAAKHGL MQHNRRHPNG GCTVRTHVCE CGKAFFQKNH LMLHQRQHLE  60
   61 TKPAISQQQV C

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.221849
Match: 1x6hA
Description: Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
structure-specific DNA binding 1.48624530884061 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
double-stranded DNA binding 1.18599503594288 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle