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View Structure Prediction Details

Protein: tum-PA
Organism: Drosophila melanogaster
Length: 625 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tum-PA.

Description E-value Query
Range
Subject
Range
gi|8919867 - gi|8919867|emb|CAB96203.1| acGAP protein [Drosophila melanogaster]
322.0 [0..1] [625..1]

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Predicted Domain #1
Region A:
Residues: [1-289]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALSALASFD DLRRCMQVLT DGTPEEEFLR FLRMFEQYHE KCAGYAAETA RIQNELDKSL  60
   61 TKMGDLEGKL FHARRIIDME IKARRQAEHE RDAMESKIMA VADLLRHERN LNNETRDKLA 120
  121 FLHTLPSSRK RKSLNAVRED KSYGDINSTG SLLSDLSITH SEDDFLDVRT SKSWREHRPS 180
  181 LPKNQIPSVG NKRSRLSTGL NGSMSGTTPT TGKSRRSSVG IGVEQHTVDV GQGAERFCAT 240
  241 TKVTIPQDGQ GVIRAESTIE SLPVIAGNER IGDGLSSTPR RSVLKEATA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.09691
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [290-375]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPLTPVNAMA PHVVAESGTP LQHRPLMRNH TFSQKTFLRG DNCVQCQKRI RFGAVGLRCR  60
   61 DCPVRCHIDC RYLLTVSCVP QTGTPT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.67
Match: 1r79A
Description: Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.71288992341677 bayes_pls_golite062009
GTPase regulator activity 2.43859890356027 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.42148330229896 bayes_pls_golite062009
enzyme regulator activity 1.78173505822139 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 1.76217210688028 bayes_pls_golite062009
small GTPase regulator activity 1.73820712435638 bayes_pls_golite062009
protein binding 1.21002143294224 bayes_pls_golite062009
transcription regulator activity 1.03969156339274 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.02645318226458 bayes_pls_golite062009
Ras GTPase activator activity 0.854618067843974 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.716569837044966 bayes_pls_golite062009
GTPase activator activity 0.531562206762648 bayes_pls_golite062009
nucleic acid binding 0.481861684281161 bayes_pls_golite062009
DNA binding 0.416562049130511 bayes_pls_golite062009
enzyme activator activity 0.160536263083511 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [376-625]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKTMTGYVTD FAPSIAPMIP ALIVHCVNEI EARGLTEVGL YRLSSSEREY KALKEQFLRG  60
   61 KATPHLGNTD IYVLCCCVKD FLRSLTEPLI PTSQWKDFAN AVQNPDTKTA QDMLVKSVKQ 120
  121 LPQANRDTLA FLILHFQRIA QCPVVLMPID NISLIFGPTI VGYSTPDPDQ HAIYTEVFTQ 180
  181 KQVMKALLEL PVSFWEQYIV IDPTRTPATV IKRVPSNKND LLSLYATPFK GGTIKKRKFY 240
  241 GTPPASAHKK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.045757
Match: 2ovjA
Description: No description for 2ovjA was found.

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