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View Structure Prediction Details

Protein: TppII-PD
Organism: Drosophila melanogaster
Length: 1441 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TppII-PD.

Description E-value Query
Range
Subject
Range
gi|25009987 - gi|25009987|gb|AAN71159.1| GH07765p [Drosophila melanogaster]
1372.0 [0..1] [1441..1]

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Predicted Domain #1
Region A:
Residues: [1-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNRFRLVHK QLRLYKNFGL LGQKASVGLT LPIISLSRPY MAYMGTERSV VMITAPATKE  60
   61 FAESSERSNS SKKTTNKEQS DKSAESRMAT SGIVESFPTG ALVPKAETGV LNFLQKYPEY 120
  121 DGRDVTIAIF DSGVDPRATG LETLCDGKTV KVIERYDCSG CGDVDMKKKV TPDENGNIKG 180
  181 LSGNSLKLSP ELMALNTD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.26
Match: 2e1pA
Description: No description for 2e1pA was found.

Predicted Domain #2
Region A:
Residues: [199-882]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEKAVRVGLK SFSDLLPSKV RNNIVAQAKL KHWDKPHKTA TANASRKIVE FESQNPGEAS  60
   61 KLPWDKKILK ENLDFELEML NSYEKVYGDI KTSYDCILFP TADGWLTIVD TTEQGDLDQA 120
  121 LRIGEYSRTH ETRNVDDFLS ISVNVHDEGN VLEVVGMSSP HGTHVSSIAS GNHSSRDVDG 180
  181 VAPNAKIVSM TIGDGRLGSM ETGTALVRAM TKVMELCRDG RRIDVINMSY GEHANWSNSG 240
  241 RIGELMNEVV NKYGVVWVAS AGNHGPALCT VGTPPDISQP SLIGVGAYVS PQMMEAEYAM 300
  301 REKLPGNVYT WTSRDPCIDG GQGVTVCAPG GAIASVPQFT MSKSQLMNGT SMAAPHVAGA 360
  361 VALLISGLKQ QNIEYSPYSI KRAISVTATK LGYVDPFAQG HGLLNVEKAF EHLTEHRQSK 420
  421 DNMLRFSVRV GNNADKGIHL RQGVQRNSID YNVYIEPIFY NDKEADPKDK FNFNVRLNLI 480
  481 ASQPWVQCGA FLDLSYGTRS IAVRVDPTGL QPGVHSAVIR AYDTDCVQKG SLFEIPVTVV 540
  541 QPHVLESDQN TPVFEPASSK GDNSVEFQPN TIQRDFILVP ERATWAELRM RITDPNRGED 600
  601 IGKFFVHTNQ LLPKQSCRKL ETMKIVSVGS ENESIMAFKV KSGRILELCI AKYWSNYGQS 660
  661 HLKYSLRFRG VEAHNPNAYV MHAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.39794
Match: 1r6vA
Description: Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.27205998189496 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.98068870917241 bayes_pls_golite062009
endopeptidase activity 2.34981838083066 bayes_pls_golite062009
hydrolase activity 1.91868221854892 bayes_pls_golite062009
serine hydrolase activity 1.90036575189745 bayes_pls_golite062009
serine-type peptidase activity 1.89198766955068 bayes_pls_golite062009
serine-type endopeptidase activity 1.23150012549143 bayes_pls_golite062009
binding 0.929059396533194 bayes_pls_golite062009
protein binding 0.688150050556688 bayes_pls_golite062009
catalytic activity 0.597535457699629 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [883-1111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGIHKLEIEA LVAEDVQPQL QLKNAEVVLK PTEAKISPLS ATRDVIPDGR QVYQNLLAFN  60
   61 LNVAKAADVS IYAPIFNDLL YEAEFESQMW MLFDANKALV ATGDAHSHTS FTKLDKGEYT 120
  121 IRLQVRHEKR DLLEKISEAN LVASFKLTSP LTLDFYENYN QCIVGGRKYV SSPLRLSTRV 180
  181 LYIAPITQER LTKANLPAQC AWLSGNLVFP QDEVGRRVAQ HPFTYILNP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1112-1265]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEKKSHTNGS SNGSSAAGST ATAAAVTTAN GAKPKAPATP QAATSVTNPA AGDGISVQND  60
   61 PPVDSSGSPA SPKKGKANAD DYAESFRDFQ CSQIVKCELE MAEKIYNDVV AAHPKHLQAN 120
  121 LLLIQNIESN QLKSQLPLTF VNAQKTSPPE AGES

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1266-1441]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADKQKEDQKK VRSALERIVK LADKVIQETD SEALLSYYGL KNDTRADAAK IKTNMDKQKN  60
   61 TLIEALSKKG IAVAKLAVLD DCIKDSLAEI NELYTEIIKF VDANDSKAIQ FALWHAYAHG 120
  121 HYGRMYKYVV KLIEEKRTRD HFVELAAING ALGHEHIRTV INRMMITAFP SSFRLF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle