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View Structure Prediction Details

Protein: fra-PB
Organism: Drosophila melanogaster
Length: 1375 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fra-PB.

Description E-value Query
Range		 Subject
Range
gi|1621115, gi|7... - pir||T13822 frazzled gene protein - fruit fly (Drosophila melanogaster), gi|1621115|gb|AAC47314.1| ...
 860.0 [0..19] [1375..19]

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Predicted Domain #1
Region A:
Residues: [1-123] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAITTNRSSR TLWNWLLSSC LIFQLIGSSL ASQALSFTLE PQDAVVPEGH SVLLQCAGTA  60
   61 SIGRGGKSKS NLPSSVSIRW RGPDGQDLVI VGDTFRTQLK NGSLYISSVE ENRGLTGAYQ 120
  121 CLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.522879
Match: 1cs6A
Description: Axonin-1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [124-348] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAEGVGSILS RPALVAIVRQ PDLNQDFLET YLLPGQTAYF RCMLGEANWQ EGVKHSVQWL  60
   61 KDDLPLPLDK LRMVVLPNGA LEIDEVGPSD RGSYQCNVTS GSSSRLSSKT NLNIKKPSDP 120
  121 GAENSVAPSF LVGPSPKTVR EGDTVTLDCV ANGVPKPQIK WLRNGMDLDF NDLDSRFSIV 180
  181 GTGSLQISSA EDIDSGNYQC RASNTVDSLD AQATVQVQEP PKFIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.221849
Match: 1p53A
Description: The Crystal Structure of ICAM-1 D3-D5 fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
fibroblast growth factor 1 binding 6.68503380812062 bayes_pls_golite062009
fibroblast growth factor binding 3.54458347746523 bayes_pls_golite062009
receptor activity 3.43161288468336 bayes_pls_golite062009
transmembrane receptor activity 3.21639072755286 bayes_pls_golite062009
fibroblast growth factor receptor activity 3.20458334492494 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
olfactory receptor activity 3.11478925068162 bayes_pls_golite062009
peptide antigen binding 2.94721224577771 bayes_pls_golite062009
molecular transducer activity 2.65769780435188 bayes_pls_golite062009
signal transducer activity 2.65769780435188 bayes_pls_golite062009
growth factor binding 2.28613301180608 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.52958974617075 bayes_pls_golite062009
cell adhesion molecule binding 1.36789541796983 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.30657787244536 bayes_pls_golite062009
protein tyrosine kinase activity 0.904613290855333 bayes_pls_golite062009
protein complex binding 0.83543827718565 bayes_pls_golite062009
receptor binding 0.632627479346393 bayes_pls_golite062009
cytokine binding 0.631436442105379 bayes_pls_golite062009
IgG binding 0.61723245594762 bayes_pls_golite062009
nucleic acid binding 0.394338877297952 bayes_pls_golite062009
cytokine receptor activity 0.34165331857492 bayes_pls_golite062009
integrin binding 0.32413307774101 bayes_pls_golite062009
transcription regulator activity 0.316848380982695 bayes_pls_golite062009
DNA binding 0.304320681250924 bayes_pls_golite062009
peptide binding 0.0686742956437796 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [349-439] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APKDTTAHEK DEPELKCDIW GKPKPVIRWL KNGDLITPND YMQLVDGHNL KILGLLNSDA  60
   61 GMFQCVGTNA AGSVHAAARL RVVPQGDSPE Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.522879
Match: 2iepA
Description: No description for 2iepA was found.

Predicted Domain #4
Region A:
Residues: [440-556] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPSVPHPGGK PLDSGLQARL PSQPRDLVAQ IVKSRFVTLS WVEPLQNAGD VVYYTVYYKM  60
   61 NNSEREQKMV TKSHDDQQVN IQSLLPGRTY QFRVEANTNF GSGASSAPLE VSTQPEV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.154902
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #5
Region A:
Residues: [557-655] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIAGPPRNFE GYARSHKEIY VKWEEPTVTN GEILKYRVYY SENDSGADLY HDSTALEAVL  60
   61 TELRPHTDYV ISVVPFNRNG MGDSSAEIRV KTFSSTPSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 1x5gA
Description: The solution structure of the second fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ankyrin binding 4.69755754047169 bayes_pls_golite062009
cytokine binding 4.43581512268554 bayes_pls_golite062009
transmembrane receptor activity 4.21125462030555 bayes_pls_golite062009
receptor activity 4.09185309744435 bayes_pls_golite062009
cytokine receptor activity 4.08668869714207 bayes_pls_golite062009
growth factor binding 4.06808996928726 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
molecular transducer activity 3.24090483126624 bayes_pls_golite062009
signal transducer activity 3.24090483126624 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
prolactin receptor activity 2.15346920063421 bayes_pls_golite062009
peptide hormone binding 2.12033076929638 bayes_pls_golite062009
polysaccharide binding 1.69642470905172 bayes_pls_golite062009
interleukin-6 binding 1.68148907423073 bayes_pls_golite062009
interleukin-6 receptor activity 1.68148907423073 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
axon guidance receptor activity 1.64934167161651 bayes_pls_golite062009
glycosaminoglycan binding 1.6158868405814 bayes_pls_golite062009
heparin binding 1.40418056272895 bayes_pls_golite062009
receptor binding 1.31676259534833 bayes_pls_golite062009
interleukin-11 receptor activity 0.89226024139982 bayes_pls_golite062009
interleukin-11 binding 0.89226024139982 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 0.80236858232025 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
transcription activator activity 0.529736394173061 bayes_pls_golite062009
hormone binding 0.49524185948356 bayes_pls_golite062009
transcription regulator activity 0.470959482317512 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
nucleic acid binding 0.399167806498504 bayes_pls_golite062009
DNA binding 0.310798383307903 bayes_pls_golite062009
pattern binding 0.30071837231983 bayes_pls_golite062009
protein tyrosine kinase activity 0.298447910128479 bayes_pls_golite062009
peptide binding 0.25993774667015 bayes_pls_golite062009
transcription factor binding 0.210682741845199 bayes_pls_golite062009
oncostatin-M receptor activity 0.162564792938799 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.162564792938799 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
cell surface binding 0.0745834027611858 bayes_pls_golite062009
growth factor activity 0.0477008672713168 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [656-752] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPNNVTLEVT SSSSITVHWE PPAEEDRNGQ ITGYKIRYRK FKDAPQVKST PANIRYFELS  60
   61 NLDRNAEYQV KIAAMTVNGS GPFTEWNRAN TLENDLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1x5hA
Description: The solution structure of the third fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ankyrin binding 4.69755754047169 bayes_pls_golite062009
cytokine binding 4.43581512268554 bayes_pls_golite062009
transmembrane receptor activity 4.21125462030555 bayes_pls_golite062009
receptor activity 4.09185309744435 bayes_pls_golite062009
cytokine receptor activity 4.08668869714207 bayes_pls_golite062009
growth factor binding 4.06808996928726 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
molecular transducer activity 3.24090483126624 bayes_pls_golite062009
signal transducer activity 3.24090483126624 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
prolactin receptor activity 2.15346920063421 bayes_pls_golite062009
peptide hormone binding 2.12033076929638 bayes_pls_golite062009
polysaccharide binding 1.69642470905172 bayes_pls_golite062009
interleukin-6 binding 1.68148907423073 bayes_pls_golite062009
interleukin-6 receptor activity 1.68148907423073 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
axon guidance receptor activity 1.64934167161651 bayes_pls_golite062009
glycosaminoglycan binding 1.6158868405814 bayes_pls_golite062009
heparin binding 1.40418056272895 bayes_pls_golite062009
receptor binding 1.31676259534833 bayes_pls_golite062009
interleukin-11 receptor activity 0.89226024139982 bayes_pls_golite062009
interleukin-11 binding 0.89226024139982 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 0.80236858232025 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
transcription activator activity 0.529736394173061 bayes_pls_golite062009
hormone binding 0.49524185948356 bayes_pls_golite062009
transcription regulator activity 0.470959482317512 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
nucleic acid binding 0.399167806498504 bayes_pls_golite062009
DNA binding 0.310798383307903 bayes_pls_golite062009
pattern binding 0.30071837231983 bayes_pls_golite062009
protein tyrosine kinase activity 0.298447910128479 bayes_pls_golite062009
peptide binding 0.25993774667015 bayes_pls_golite062009
transcription factor binding 0.210682741845199 bayes_pls_golite062009
oncostatin-M receptor activity 0.162564792938799 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.162564792938799 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
cell surface binding 0.0745834027611858 bayes_pls_golite062009
growth factor activity 0.0477008672713168 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [753-845] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETQVPGKPIW ISIHPGANNI ALHWGPPQHP EIKIRNYVLG WGRGIPDENT IELKETERYH  60
   61 ILKNLESNMD YVVSLRARNV KGDGPPIYDN IKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1x5iA
Description: The solution structure of the fourth fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ankyrin binding 4.69755754047169 bayes_pls_golite062009
cytokine binding 4.43581512268554 bayes_pls_golite062009
transmembrane receptor activity 4.21125462030555 bayes_pls_golite062009
receptor activity 4.09185309744435 bayes_pls_golite062009
cytokine receptor activity 4.08668869714207 bayes_pls_golite062009
growth factor binding 4.06808996928726 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
molecular transducer activity 3.24090483126624 bayes_pls_golite062009
signal transducer activity 3.24090483126624 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
prolactin receptor activity 2.15346920063421 bayes_pls_golite062009
peptide hormone binding 2.12033076929638 bayes_pls_golite062009
polysaccharide binding 1.69642470905172 bayes_pls_golite062009
interleukin-6 binding 1.68148907423073 bayes_pls_golite062009
interleukin-6 receptor activity 1.68148907423073 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
axon guidance receptor activity 1.64934167161651 bayes_pls_golite062009
glycosaminoglycan binding 1.6158868405814 bayes_pls_golite062009
heparin binding 1.40418056272895 bayes_pls_golite062009
receptor binding 1.31676259534833 bayes_pls_golite062009
interleukin-11 receptor activity 0.89226024139982 bayes_pls_golite062009
interleukin-11 binding 0.89226024139982 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 0.80236858232025 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
transcription activator activity 0.529736394173061 bayes_pls_golite062009
hormone binding 0.49524185948356 bayes_pls_golite062009
transcription regulator activity 0.470959482317512 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
nucleic acid binding 0.399167806498504 bayes_pls_golite062009
DNA binding 0.310798383307903 bayes_pls_golite062009
pattern binding 0.30071837231983 bayes_pls_golite062009
protein tyrosine kinase activity 0.298447910128479 bayes_pls_golite062009
peptide binding 0.25993774667015 bayes_pls_golite062009
transcription factor binding 0.210682741845199 bayes_pls_golite062009
oncostatin-M receptor activity 0.162564792938799 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.162564792938799 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
cell surface binding 0.0745834027611858 bayes_pls_golite062009
growth factor activity 0.0477008672713168 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [846-938] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDEEPVDAPT PLEVPVGLRA ITMSSSSIVV YWIDTMLNKN QHVTDNRHYT VSYGITGSNR  60
   61 YRYHNTTDLN CMINDLRPNT QYEFAVKVVK GRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.0
Match: 1qg3A
Description: Integin beta-4 subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [939-1203] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESSWSMSVLN STYQNVPVTP PREVTVRLDE MNPPTVIVQW IPPKHTLGQI TGYNIYYTTD  60
   61 TTKRDRDWSV EAFAGEETML MLPNLKPYTT YYFKVQARTT KGANNAPFSA LVSYTTSAAV 120
  121 TMQEPDTIAK GIDNEKLLYI IIAATAVVLL VVLLGVLLLC RRKPQSSPEH TKKSYQKNNV 180
  181 GVPKPPDLWI HHDQMELKNI DKGLHTVTPV CSDGASSSGA LTLPRSVVHS EYEVETPVPG 240
  241 HVTNSLDKRS YVPGYMTTSM NGTME

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 1cfbA
Description: CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS
Matching Structure (courtesy of the PDB):

Predicted Domain #10
Region A:
Residues: [1204-1375] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPQYPRTQYS HQNRSHMTME AGLSQQSLTQ PQSNSMAQTP EHPYGGYDAN FCNAGNAAAG  60
   61 NGCVSTIESS KRGHPLKSFS VPGPPPTGGA TPVTKHTPAV TIRPQNQSPY KKPSFSAATP 120
  121 NRLQGGGSVV HSTDEIQRLA PSTSTEELNQ EMANLEGLMK DLSAITANEF EC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle