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View Structure Prediction Details

Protein: Buffy-PA
Organism: Drosophila melanogaster
Length: 299 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Buffy-PA.

Description E-value Query
Range
Subject
Range
gi|7263182 - gi|7263182|gb|AAF44120.1|AF237864_1 Bcl-2-like protein BUFFY [Drosophila melanogaster]
346.0 [0..1] [299..15]

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Predicted Domain #1
Region A:
Residues: [1-299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGTSYPTNN DNFSNGFPMA TTQSERLLQA QNRRKFSFPA TLHSASLLEV GGGPKETTRR  60
   61 RLSNVSDAVT RKLSYTIGWK AAQIPAQDII SQGRCLCGHY IKRRLRRSGL FNKKLGLQRI 120
  121 RSILGSTSMG IVRDVFPAVQ VLGDELERMH PRIYNGVARQ ICRNPGGEFH TPDAVSLLLG 180
  181 AVGRELFRVE ITWSKVISLF AIAGGLSVDC VRQGHPEYLP KLMESVSEVI EDELVPWINE 240
  241 NGGWSGINTH VLPTTNSLNP LEWTTLVIGV VFGLILVFMI LRFIFNLIVP KIYQRFTNS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.0
Match: 1f16A
Description: Proapoptotic molecule Bax
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.32513226847241 bayes_pls_golite062009
binding 1.68532136060219 bayes_pls_golite062009
protein dimerization activity 1.00006462805615 bayes_pls_golite062009
protein heterodimerization activity 0.88825596389518 bayes_pls_golite062009
BH3 domain binding 0.73278409982916 bayes_pls_golite062009
death domain binding 0.583637336305401 bayes_pls_golite062009
BH domain binding 0.513227895728431 bayes_pls_golite062009
caspase inhibitor activity 0.0810673056766702 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle