YRC Public Data Repository - Protein Structure Prediction

Protein:	Prosbeta5-PA, Pr...
Organism:	Drosophila melanogaster
Length:	282 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Prosbeta5-PA, Pr....

Description	E-value	Query Range	Subject Range
gi\|6715438 - gi\|6715438\|gb\|AAF26416.1\|AF217726_1 20S proteasome beta5 subunit [Drosophila melanogaster]	282.0	[0..1]	[282..1]
PSB8_RAT - Proteasome subunit beta type-8 OS=Rattus norvegicus GN=Psmb8 PE=1 SV=3	269.0	[0..1]	[275..1]
gi\|109070671 - gi\|109070671\|ref\|XP_001115562.1\| PREDICTED: similar to proteasome beta 8 subunit isoform E2 proprote...	268.0	[0..1]	[276..1]
gi\|972988, gi\|97... - gi\|972988\|gb\|AAA75036.1\| 20S proteasome subunit Lmp7 [Mus musculus], gi\|972986\|gb\|AAA75035.1\| 20S pr...	263.0	[0..1]	[277..1]
gi\|18157533 - gi\|18157533\|dbj\|BAB83848.1\| PSMB8-A [Oryzias latipes]	263.0	[0..1]	[274..1]
gi\|114606757 - gi\|114606757\|ref\|XP_001167272.1\| PREDICTED: proteasome beta 8 subunit isoform 3 [Pan troglodytes]	263.0	[0..1]	[276..1]
gi\|123230977, gi... - gi\|73747875\|ref\|NP_683720.2\| proteasome beta 8 subunit isoform E2 proprotein [Homo sapiens], gi\|5620... gi\|208967166 - gi\|208967166\|dbj\|BAG73597.1\| proteasome (prosome, macropain) subunit beta type 8 [synthetic construc...	263.0	[0..1]	[276..1]

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Predicted Domain #1

Region A:
Residues: [1-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALAEICKIS NAPYMRPNAW SSADVEEEQK GLMCNLANPY TLAAPPFENP LHNLNQIQAN  60
   61 GDKTGVKINF DHGTTTLGFK FKGGVLLAVD SRATGGSYIG SQSMKKIVEI NQFMLGTLAG 120
  121 GAADCVYWDR VLSKECRLHE LRNKERISVA AASKIMANIA HEYKGMGLSM GMMLAGYDKR 180
  181 GPGLYYVDSE GSRTPGNLFS VGSGSLYAYG VLDSGYHWDL EDKEAQELGR RAIYHATFRD 240
  241 AYSGGIIRVY HIKEDGWVNI SNTDCMELHY MYQEQLKQQA AK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.522879
Match:	1iruL
Description:	Proteasome beta subunit (catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009
binding	0.982918122186083	bayes_pls_golite062009
nucleic acid binding	0.448212653390607	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: