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View Structure Prediction Details

Protein: psq-PB, psq-PC
Organism: Drosophila melanogaster
Length: 1064 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for psq-PB, psq-PC.

Description E-value Query
Range
Subject
Range
gi|1149500, gi|2... - pir||S66149 gene pipsqueak protein A long form - fruit fly (Drosophila melanogaster), gi|1149500|em...
610.0 [0..605] [1061..605]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVRGHQYF SLRWNNYQNT MTSVFQQLRE DLSFVDVTLS CEHGSLKAHK VVLSACSTYF  60
   61 QKLLLENPCK HPTIILPADI IFTDLKTIID FVYRGEIDVT ESELQGLLRT AEQLKIKGLC 120
  121 ETAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 2nn2A
Description: No description for 2nn2A was found.

Predicted Domain #2
Region A:
Residues: [125-272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NADDLNDAAT ATITVSENIQ QAVVGNIVNA AIVPGAPSPS LEQQQQHHQQ QQQQQAQEQH  60
   61 QQQQVHAQQQ QQQQQQINAA LLTQHGVSSG SVSLSGQLLS SSASGSSGSL AGGQQASQTP 120
  121 SGLQPTPRKS RLKRSKSPDL SSGGGAGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [273-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGGSSSGSTQ QQPQPAHHHH PQTILIQGQN PNSIVSLQQT ADGNYIPVSG SGDDSDAEDH  60
   61 EHEHNHGHGH GHGGHTHGHG HSHEHSHDHE HEHKPNKICK TEHSVASPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.30103
Match: 2dlqA
Description: No description for 2dlqA was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [382-441]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNSSSASNNA AGVSGVTSTG QAIVTQIVVA RDGKDTKNMT SLGMGMNGGL LGVPMGFLDF  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.24
Match: 2qfiA
Description: No description for 2qfiA was found.

Predicted Domain #5
Region A:
Residues: [442-608]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPEPPAPSAT PVTVTEHVDL SCNPSTDTRD LSNTTEPLDI DNHLAQQIHR LDQSPMHSIS  60
   61 HHHTGDESNS NLVQHIKSEV IEAKHLAAQH HALSQAQQQH AHHQAHQQHQ QHQQQQHQQQ 120
  121 QQHLHAQQLL AQSQLQQQQQ QQQQQQQHHQ QQQQQAAAAA AAAGVHG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [609-714]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHGGHVTHAD IGGATVMEID PSQIKHEPGM IITPEIVNMM SSGHMDMYNS DTSEDSMMIA  60
   61 NGSPHDQKEP HYTNLDQQHG LGGSVCGPGP GGAGGGGGMS GGAGSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [715-833]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGEKGQFNGP KAWTQDDMNS ALDALKNQNM SLTKASAIYG IPSTTLWQRA HRMGIETPKK  60
   61 EGGTKSWNED ALQNALEALR SGQISANKAS KAFGIPSSTL YKIARREGIR LAAPFNAAP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [834-1064]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTWTPEDLER ALEAIRAGNT SVQKASAEFG IPTGTLYGRC KREGIELSRS NPTPWSEDAM  60
   61 NEALNSVRVG QMSINQAAIH YNLPYSSLYG RFKRGKYDVV ANTSGVALLN TSGNTTGSIE 120
  121 IIEHSQENSL HMLQQQFPYS PSPHPPTPQH HSTPQHHSSA QQGPPTPQHM QQHVVHMQQQ 180
  181 QQQQQQQSPH PGHHPQHMQQ DVVTSSSQVV HSQQQQQLQQ IYQHHGTPER S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle