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View Structure Prediction Details

Protein: FBpp0309831, lola-PI
Organism: Drosophila melanogaster
Length: 970 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0309831, lola-PI.

Description E-value Query
Range
Subject
Range
gi|73970462 - gi|73970462|ref|XP_531880.2| PREDICTED: similar to Zinc finger protein 208 [Canis familiaris]
728.0 [0..293] [968..342]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL  60
   61 LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT 120
  121 GGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 2nn2A
Description: No description for 2nn2A was found.

Predicted Domain #2
Region A:
Residues: [124-286]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAPKPESSGH HRGGKLSGAY TLEQTKRARL ATGGAMDTSG DVSGSREGSS SPSRRRRKVR  60
   61 RRSMENDAHD NSNSSVLQAA ASNQSILQQT GAGLAVSALV TTQLSSGPAA GTSSQASSTQ 120
  121 QQQPLTSTNV TKKTESAKLT SSTAAPASGA SASAAVQQAH LHQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [287-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQAQTTSDAI NTENVQAQSQ GGAQGVQGDD EDIDEGSAVG GPNSATGPNP ASASASAVHA  60
   61 GVVVKQLASV VDKSSSNHKH KIKDNSVSSV GSEMVIEPKA EYDDDAHDEN VEDLTLDEED 120
  121 MTMEELDQTA GTSQGGEGSS QTYATWQHDR SQDELGLMAQ DAQQRDPQAS KQDKGEQTE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [466-623]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAQDEFELDD CLLESNDIVI TQNKDGFVLH VKKLGNITAA KLEENQAVAQ QQGQAAVTVT  60
   61 GPAGQPTPTI TELLNAAAAS HSEPKPTLTT LTSTPIKLPS SECELINIKK IIPATTTIAT 120
  121 HHPHTSSTII HPHHIIQHVS QEPHHQEHHQ QHQTIHIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.39794
Match: 1tf3A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [624-720]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVPQTSQQHH QQQHHHQLQT VQPTHTQVQS IITAHPGQTI NLVGLRNVQL ADSKPIASRI  60
   61 RYSRGKIIGP TVQNLQIVET HEPIQHQHHE LSDGTKY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [721-970]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EISEIDLNNP NASAAIISDL VKYAEIDDIE LPDGTKIGIG FAPSEITEHM QTSGGETHIT  60
   61 TIEHEPQELQ TVHQHEQTQQ THHIHAGQLQ THHIQTVVQS SSGQQQHDQQ QHHQHHSIEL 120
  121 QDDDGVETIT PEELGMHDSS KSYTILTTRP MKEESEHDPS GMTYELSLSD SSLGPCDDPE 180
  181 SRYVCRHCGK KYRWKSTLRR HENVECGGKE PCHPCPYCSY KAKQRGNLGV HVRKHHPEKP 240
  241 QLESKRGRKV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.522879
Match: 2i13A
Description: No description for 2i13A was found.

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