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View Structure Prediction Details

Protein: FBpp0311591, Hdc...
Organism: Drosophila melanogaster
Length: 847 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0311591, Hdc....

Description E-value Query
Range
Subject
Range
gi|486934, gi|54... - sp|Q05733|DCHS_DROME Histidine decarboxylase (HDC), pir||S36337 histidine decarboxylase (EC 4.1.1.2...
847.0 [0..1] [847..1]

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Predicted Domain #1
Region A:
Residues: [1-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFKEYRQRG KEMVDYIADY LENIRERRVF PDVSPGYMRQ LLPESAPIEG EPWPKIFSDV  60
   61 ERIVMPGITH WQSPHMHAYF PALNSMPSLL GDMLADAINC LGFTWASSPA CTELEIIVMN 120
  121 WLGKMIGLPD AFLHLSSQSQ GGGVLQTTAS EATLVCLLAG RTRAIQRFHE RHPGYQDAEI 180
  181 NARLVAYCSD QAHSSVEKAA LIGLVRMRYI EADDDLAMRG KLLREAIEDD IKQGLVPFWV 240
  241 CATLGTTGSC SFDNLEEIGI VCAEHHLWLH VDAAYAGSAF ICPEFRTWLR GIERADSIAF 300
  301 NPSKWLMVHF DATALWVRDS TAVHRTFNVE PLYLQHENSG VAVDFMHWQI PLSRRFRALK 360
  361 VWFVLRSYGI KGLQRHIREG VRLAQKFEAL VLADHRFELP AKRHLGLVVF RIRGDNEITE 420
  421 KLLKRLNHRG NLHCIPSSLK GQYVIRFTIT STHTTLDDIV KDWMEIRQVA STVLEEMNIT 480
  481 ISNR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 118.0
Match: 1js3A
Description: DOPA decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4-aminobutyrate transaminase activity 2.49533238079952 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
5-aminolevulinate synthase activity 1.01853440922526 bayes_pls_golite062009
transferase activity 0.737426388870721 bayes_pls_golite062009
binding 0.252160165096264 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 0.130698724135981 bayes_pls_golite062009
carbon-carbon lyase activity 0.11598778799668 bayes_pls_golite062009
aromatic-L-amino-acid decarboxylase activity 0.10589462882093 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [485-624]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VYLKETKEKN EAFGSSLLLS NSPLSPKVVN GSFAAIFDAD EFLAKTYAGV RIAHQESPSM  60
   61 RRRVRGILMS GKQFSLDSHM DVVVQTTLDA GNGATRTSTT NSYGHTTSAA QANSERQASI 120
  121 QEDNEESPEE TELLSLCRTS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [625-847]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVPSPEHAHS LSTPSRSCSS SSHSLIHSLT QSSPRSSPVN QFRPITLCAV PSQSQLSMPL  60
   61 AMPLPNRNVT VSVDSLLNPV TTCNVYHGKR FLEPLENLAQ TSASFSSSIF RLPTPIATPT 120
  121 RESPEDPDWP AKTFSQLLLE RYSSQSQSLG NNSSTESSSL SGGATPTPTP MSSLDELVTP 180
  181 LLLSFASPSQ PMLSAHGIGE GQREQGSDSD ATVCSTTSSM ESL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle