YRC Public Data Repository - Protein Structure Prediction

Protein:	Prosalpha7-PA
Organism:	Drosophila melanogaster
Length:	253 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Prosalpha7-PA.

Description	E-value	Query Range	Subject Range
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	271.0	[0..6]	[235..8]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p... PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1	267.0	[0..6]	[235..8]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	266.0	[0..6]	[236..8]
PSA_THEK1 - Proteasome subunit alpha OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=psmA PE=3 SV=1 PSA_THEK1, PSMA_... - Proteasome subunit alpha OS=Thermococcus sp. (strain KS-1) GN=psmA PE=3 SV=1, Proteasome subunit alp... gi\|11265988 - pir\|\|T43887 proteasome alpha chain [imported] - Thermococcus sp	263.0	[0..6]	[238..8]
PSMA_PYRKO - Proteasome subunit alpha OS=Pyrococcus kodakaraensis GN=psmA PE=3 SV=1 PSA_THEKO - Proteasome subunit alpha OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=ps...	262.0	[0..6]	[238..8]
gi\|7435881 - pir\|\|D69191 proteasome, alpha subunit - Methanobacterium thermoautotrophicum (strain Delta H) PSA_METTH - Proteasome subunit alpha OS=Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / J...	260.0	[0..5]	[248..6]
PSA4A_ARATH - Proteasome subunit alpha type-4-A OS=Arabidopsis thaliana GN=PAC1 PE=1 SV=1	255.0	[0..4]	[248..1]
gi\|159124347 - gi\|159124347\|gb\|EDP49465.1\| proteasome component Pre9, putative [Aspergillus fumigatus A1163] gi\|70991873, gi\|... - gi\|70991873\|ref\|XP_750785.1\| proteasome component Pre9 [Aspergillus fumigatus Af293], gi\|66848418\|gb... gi\|119470082, gi... - gi\|119470082\|ref\|XP_001258013.1\| proteasome component Pre9, putative [Neosartorya fischeri NRRL 181]...	255.0	[0..4]	[248..1]
PSA4_SPIOL - Proteasome subunit alpha type-4 OS=Spinacia oleracea GN=PAC1 PE=2 SV=1	255.0	[0..4]	[248..1]
gi\|145020008, gi... - gi\|39946336\|ref\|XP_362705.1\| conserved hypothetical protein [Magnaporthe grisea 70-15], gb\|EAA57374.... gi\|59802961 - gi\|59802961\|gb\|AAX07682.1\| proteasome subunit alpha type 4-like protein [Magnaporthe grisea]	254.0	[0..4]	[251..1]

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Predicted Domain #1

Region A:
Residues: [1-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTIGTGYDL SASQFSPDGR VFQIDYASKA VEKSGTVIGI RGKDAVVLAV EKIITSKLYE  60
   61 PDAGGRIFTI EKNIGMAVAG LVADGNFVAD IARQEAANYR QQFEQAIPLK HLCHRVAGYV 120
  121 HAYTLYSAVR PFGLSIILAS WDEVEGPQLY KIEPSGSSFG YFACASGKAK QLAKTEMEKL 180
  181 KMDMRTDELV ESAGEIIYKV HDELKDKDFR FEMGLVGRVT GGLHLINPSE LTEKARKAGD 240
  241 AANKDEDSDN ETH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.0
Match:	1iruG
Description:	Proteasome alpha subunit (non-catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009
binding	0.982918122186083	bayes_pls_golite062009
nucleic acid binding	0.448212653390607	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: