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View Structure Prediction Details

Protein: Pkn-PF
Organism: Drosophila melanogaster
Length: 1205 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pkn-PF.

Description E-value Query
Range
Subject
Range
Pkn-PB - The gene Protein kinase related to protein kinase N is referred to in FlyBase by the symbol Dmel\Pkn...
927.0 [0..20] [1205..5]

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Predicted Domain #1
Region A:
Residues: [1-354]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALTMNMVFL KDLRSRLKGY LHGEYIKHPV LYELSHKYGF TENLPESCMS IRLEEIKEAI  60
   61 RREIRKELKI KEGAEKLREV AKDRRSLSDV AVLVKKSKSK LAELKSELQE LESQILLTSA 120
  121 NTAVNSNGQE SITACIDPNG GFLVSGAVGG LGGGNTALEG GAPATANDKV LASLEKQLQI 180
  181 EMKVKTGAEN MIQSLGIGCD KKLLAEAHQM LADSKAKIEF LRLRIIKVKQ NREQADRLKA 240
  241 SRQMIDEHGQ TIGGNNSSQP QSLETTLEER IEELRHRLRI EAAVVDGAKN VIRTLQTANR 300
  301 APDKKALQEA HGRLSESSRK LDLLRYSLDL RRQELPADSP AAQQLKTELQ IVQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.09691
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [355-420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STSPAPVTYT SLQSGQAGIL GGKPYQSVSS LGRCASVTGK LEVRLLGCQD LLEDVPGRSR  60
   61 RDKDNN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [421-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPGDLRSFV KGVTSRSSSK SYSVKDETSI EIMAVIKLDN ITVGQTSWKQ CSQQAWDQRF  60
   61 SIDLDRSREL EIGVYWRDWR SLCAVKVLRL EEFIDDVRHG MALQLEPQGL LFAEVKFLNP 120
  121 MISQKPKLRR QRMIFNRQQA KNISRAKQMN INVATWGRLL KRNAPNHVHM GSAGSGSSLT 180
  181 GSSPMVVGGS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.522879
Match: 1gmiA
Description: Domain from protein kinase C epsilon
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
calcium-dependent phospholipid binding 3.93415448210371 bayes_pls_golite062009
binding 2.77482286467294 bayes_pls_golite062009
phospholipid binding 2.74013385479058 bayes_pls_golite062009
neurexin binding 1.99616093461872 bayes_pls_golite062009
lipid binding 1.79802914584378 bayes_pls_golite062009
protein binding 1.33917246836907 bayes_pls_golite062009
receptor activity 1.33810899162617 bayes_pls_golite062009
transporter activity 1.2628067945512 bayes_pls_golite062009
signal transducer activity 1.10701462579828 bayes_pls_golite062009
molecular transducer activity 1.10701462579828 bayes_pls_golite062009
substrate-specific transporter activity 0.816751946072324 bayes_pls_golite062009
SNARE binding 0.3731056408292 bayes_pls_golite062009
profilin binding 0.32399339703241 bayes_pls_golite062009
syntaxin-1 binding 0.273890767897551 bayes_pls_golite062009
calmodulin binding 0.26906635924237 bayes_pls_golite062009
receptor binding 0.189665306346323 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [611-1139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDSESPISRT PSSDALVEPE PYTPGEQAQN LEFDPDAGIN EHVETPGEYP DPAASGLSGM  60
   61 RPLSMHMQGI SVLPPESPPV ATGAAGRPNT LSLQMPGASK GQVIQGGRTA APTTAPPPPP 120
  121 VLKATSTTPI LDQEVIPQLG KLYVGSSQQQ YAQQSSPIIQ EPATPTIYGN SAAAGAPQFP 180
  181 QPAQRQEKQP PQQQPIYANQ YELNVAKAAA AASVYSPSSS TTSNSNQQQQ QQRRNVARGL 240
  241 QYRESGGLET GRAGKQPPNA GMLSMDNFRL LSVLGRGHFG KVILSQLRSN NQYYAIKALK 300
  301 KGDIIARDEV ESLLSEKRIF EVANAMRHPF LVNLYSCFQT EQHVCFVMEY AAGGDLMMHI 360
  361 HTDVFLEPRA VFYAACVVLG LQYLHENKII YRDLKLDNLL LDTEGYVKIA DFGLCKEGMG 420
  421 FGDRTGTFCG TPEFLAPEVL TETSYTRAVD WWGLGVLIFE MLVGESPFPG DDEEEVFDSI 480
  481 VNDEVRYPRF LSLEAIAVMR RLLRKNPERR LGSSERDAED VKKQAFFRS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.39794
Match: 2h8hA
Description: No description for 2h8hA was found.

Predicted Domain #5
Region A:
Residues: [1140-1205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVWDDLLLRK VKPPFVPTIN HLEDVSNFDE EFTSEKAQLT PPKEPRHLTE EEQLLFQDFS  60
   61 YTAEWC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 101.0
Match: 2jdoA
Description: No description for 2jdoA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle