YRC Public Data Repository - Protein Structure Prediction

Protein:	PGRP-SC1a-PA, PG...
Organism:	Drosophila melanogaster
Length:	185 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PGRP-SC1a-PA, PG....

Description	E-value	Query Range	Subject Range
gi\|60688419, gi\|... - gi\|71896011\|ref\|NP_001025626.1\| pglyrp1 protein [Xenopus (Silurana) tropicalis], gi\|60688419\|gb\|AAH9...	198.0	[0..8]	[183..2]
PGRP2_HOLDI - Peptidoglycan-recognition protein 2 OS=Holotrichia diomphalia GN=PGRP-2 PE=1 SV=1	195.0	[0..1]	[184..1]
gi\|63033995 - gi\|63033995\|gb\|AAY27974.1\| peptidoglycan recognition protein 2 precursor [Euprymna scolopes]	193.0	[0..1]	[184..1]
gi\|37665303 - gi\|37665303\|emb\|CAD89168.1\| peptidoglycan recognition protein SC1B [Drosophila melanogaster]	191.0	[0..1]	[185..1]
gi\|54636704, gi\|... - gi\|54636704\|gb\|EAL26107.1\| GA13217 [Drosophila pseudoobscura pseudoobscura], gi\|125810568\|ref\|XP_001... gi\|125810568\|ref... - GA13217-PA [Drosophila pseudoobscura], GA13217 [Drosophila pseudoobscura pseudoobscura]	190.0	[0..1]	[183..1]
PGSC1_DROSI - Peptidoglycan-recognition protein SC1a/b OS=Drosophila simulans GN=PGRP-SC1a PE=3 SV=1	188.0	[0..1]	[185..1]
gi\|148236319, gi... - gi\|56269181\|gb\|AAH87429.1\| LOC496035 protein [Xenopus laevis], gi\|148236319\|ref\|NP_001088771.1\| hypo... UniRef90_D6QX30 - PGRP-S n=3 Tax=Xenopus RepID=D6QX30_XENTR	188.0	[0..5]	[183..1]
PGRP4_MOUSE - Peptidoglycan recognition protein 4 OS=Mus musculus GN=Pglyrp4 PE=2 SV=1	188.0	[0..20]	[183..210]

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Predicted Domain #1

Region A:
Residues: [1-185]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSKVALLLA VLVCSQYMAQ GVYVVSKAEW GGRGAKWTVG LGNYLSYAII HHTAGSYCET  60
   61 RAQCNAVLQS VQNYHMDSLG WPDIGYNFLI GGDGNVYEGR GWNNMGAHAA EWNPYSIGIS 120
  121 FLGNYNWDTL EPNMISAAQQ LLNDAVNRGQ LSSGYILYGH RQVSATECPG THIWNEIRGW 180
  181 SHWSG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.221849
Match:	1s2jA
Description:	Crystal structure of the Drosophila pattern-recognition receptor PGRP-SA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidoglycan binding	9.32313496679335	bayes_pls_golite062009
peptidoglycan receptor activity	6.51660037886232	bayes_pls_golite062009
pattern recognition receptor activity	6.45255811818702	bayes_pls_golite062009
N-acetylmuramoyl-L-alanine amidase activity	5.29207604418857	bayes_pls_golite062009
pattern binding	4.06455798515101	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3.20235326428146	bayes_pls_golite062009
receptor activity	2.69681086194598	bayes_pls_golite062009
signal transducer activity	2.24692953747972	bayes_pls_golite062009
molecular transducer activity	2.24692953747972	bayes_pls_golite062009
binding	1.78736719382897	bayes_pls_golite062009
muramyl dipeptide binding	1.16811676642278	bayes_pls_golite062009
hydrolase activity	1.14017500144843	bayes_pls_golite062009
	0.808368163500401	bayes_pls_golite062009
catalytic activity	0.628556091191359	bayes_pls_golite062009
	0.60706691535931	bayes_pls_golite062009
protein binding	0.175384917086218	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: