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View Structure Prediction Details

Protein: pwn-PA
Organism: Drosophila melanogaster
Length: 1307 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pwn-PA.

Description E-value Query
Range
Subject
Range
gi|54635375, gi|... - gi|54635375|gb|EAL24778.1| GA10760-PA [Drosophila pseudoobscura], gi|125806928|ref|XP_001360204.1| G...
406.0 [0..21] [1307..6]

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Predicted Domain #1
Region A:
Residues: [1-129]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEWLLVGIE REPGQHESVS QISPKSSSHR SPDRQRIEST MADSVNGLAE GQSSPLDVND  60
   61 NETRAERVER SASPILHDRQ PIGPNDVHFP EDLEKDVSAG RYFHYNIKPT GTFDNQDEQP 120
  121 ERTHQGIRA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [130-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKTLSQGGSS SEQSFLGRGD LRPLVSGSPI RPSPSNTATS ATAASATQAP HSPRQNGNPD  60
   61 IQDIITGIVK LLNGNVNVHA NTQGIRRPSA SRINNRGPPR ISEAQNLPID YEAQKPGTSM 120
  121 RPPPYPFDRP ERPFITGVPI PEQIVPVRPG FVSNRPPWYR NKPRPPIATS VGGNRRPLPQ 180
  181 YKPLPAPPVQ APLQPQDPLD RKNEQEKEQN HQEQPQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [346-545]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTDDVVLPTD TTYDSEFSNE DANAQYIEVS DQDTDATGGE VEDELQPPPP PPSTTNNPPT  60
   61 TPTNPSKKKH KPKPGSEKKK LPEESPQDEG FSTIIETSSV VHTVMGMSST YVPMSMDSSE 120
  121 SLGLDPSTEE VIFMTANRTP TLEPSVTSSL GTSSSSNPAS AIQPTSSKEH TKTTTTTTTT 180
  181 TSSSTSTTTS TTTPPSTESV 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [546-745]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPNSSNANTN ATPPAPYHPR PGIVLDDPEF KPGGRPRPPV QRPPAQQTLP LPAVQPTRQH  60
   61 LPPGYGEIFD VTLSAIQGPG PKGSGSQQTI NIKPYGSYAA GGGQGDIIVS ASGDDGFVSI 120
  121 DGKRTYINLF GDPTDPPAGA TTPATRLPQL PGSGSGSGSG SGTGSGGAST PGVGVSSGGG 180
  181 GGSGSSISPA APANAVTQSS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [746-1202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGYVVPETEV VDLQGHSKPQ GGAPTTNAGP TRPHYRQRPT QPPVRIDTCI VGDDSTCDQA  60
   61 QHERCKTDNG VSSCHCRPGY SRRKHREPCR RVISFHLGMR VDRIYEHRIV WDTKLMDKHS 120
  121 EPFGQLSYES IRALDSAMSM TPYSDEFMEA KVNNIYRGDP NLGGSGVYVN MTIKLDESVE 180
  181 TLRPNLRSDV QKHLLGVLHR RNNNIGNSVL YVSSPEGAVS ALQDLDECQS PELNDCHSGA 240
  241 SCSNTWGSFR CACEAGLRDP WADQPARSGR ECQACADSVC NNHGTCSYAE DGAQLCTCDS 300
  301 SHYGAQCEID GEVLGVAIGA SVAAIIIIVL TLVCLIMWSR RWQREQKNAM GSPVFGYMNT 360
  361 APLKSAGLPQ AGYQVTLEDR MRWAQIADVM AQTNHYGAEP IGPTRPSSAM FAYPNLGAMG 420
  421 MGTLGGMSLQ STMQMHPSAT LAPPVPLPRR LGLGPRS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.221849
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.279921135544 bayes_pls_golite062009
binding 1.20290372802439 bayes_pls_golite062009
receptor binding 1.07208480206832 bayes_pls_golite062009
ErbB-2 class receptor binding 0.3648038027933 bayes_pls_golite062009
ErbB-3 class receptor binding 0.0872631558320198 bayes_pls_golite062009
growth factor activity 0.04792804882584 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1203-1307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGMRTLENSS SSEEEDRADL LGRNFQVPRP KSRSNGSIAN QSGIYYDVDY EPSGNGIGNS  60
   61 SVDHLYGSQN QSVTHSSGHS HIPGPQGIPM STYTSGRAPS SYYMK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle