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View Structure Prediction Details

Protein: amos-PA
Organism: Drosophila melanogaster
Length: 198 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for amos-PA.

Description E-value Query
Range
Subject
Range
gi|5577991 - gi|5577991|gb|AAD45410.1|AF166113_1 basic helix-loop-helix transcription factor [Drosophila melanoga...
154.0 [0..1] [198..1]
gi|7804955 - gi|7804955|gb|AAF70195.1|AF253470_1 myogenic regulatory factor myf5 [Danio rerio]
101.0 [0..72] [196..1]
gi|16611800 - gi|16611800|gb|AAL27367.1| myogenic factor 5 [Equus caballus]
100.0 [0..72] [196..6]
gi|74136157, gi|... - gi|74136157|ref|NP_001027941.1| myoblast determination protein [Takifugu rubripes], gi|40074258|gb|A...
100.0 [0..31] [195..2]
gi|3721611 - gi|3721611|dbj|BAA33566.1| myf-5 [Cyprinus carpio]
96.0 [0..72] [196..1]
gi|30231224, gi|... - gi|30231224|ref|NP_034532.2| heart and neural crest derivatives expressed transcript 2 [Mus musculus...
96.0 [0..40] [197..2]
HAND2_RAT - Heart- and neural crest derivatives-expressed protein 2 OS=Rattus norvegicus GN=Hand2 PE=2 SV=1
gi|109076189 - gi|109076189|ref|XP_001085842.1| PREDICTED: similar to heart and neural crest derivatives expressed ...
gi|114596892 - gi|114596892|ref|XP_001156041.1| PREDICTED: similar to dHand protein [Pan troglodytes]
HAND2 - heart and neural crest derivatives expressed 2
HAND2_MOUSE - Heart- and neural crest derivatives-expressed protein 2 OS=Mus musculus GN=Hand2 PE=1 SV=3
gi|208968475, gi... - gi|225000970|gb|AAI72639.1| Heart and neural crest derivatives expressed transcript 2 [synthetic con...
96.0 [0..40] [197..2]
gi|45237486, gi|... - gi|45237486|emb|CAF34059.1| myoblast determination protein [Hippoglossus hippoglossus], gi|45237484|...
96.0 [0..57] [195..7]

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Predicted Domain #1
Region A:
Residues: [1-129]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTNNELMEQ FYFPDEAPAI PEFLSNDTFQ QLEQLMYQQE FSTSDSQSDG ANSCSLEMYY  60
   61 DTPSVLELEH MLNAQEQQQH HLQANPLGKN QGRSPRYWNK QQRSKPYDKL STSMSSSTSS 120
  121 ASSSSSSSA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [130-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFGGEVLKKR RLAANARERR RMNSLNDAFD KLRDVVPSLG HDRRLSKYET LQMAQAYIGD  60
   61 LVTLLSRDY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.522879
Match: 1mdyA
Description: Myod B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.48787404513864 bayes_pls_golite062009
sequence-specific DNA binding 2.31910036997977 bayes_pls_golite062009
protein binding 1.59929864805879 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 1.46304579811572 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle