YRC Public Data Repository - Protein Structure Prediction

Protein:	NC2beta-PA
Organism:	Drosophila melanogaster
Length:	183 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NC2beta-PA.

Description	E-value	Query Range	Subject Range
gi\|114646579 - gi\|114646579\|ref\|XP_509327.2\| PREDICTED: similar to Nuclear transcription factor Y, beta [Pan troglo...	181.0	[0..1]	[169..31]
gi\|50414924, gi\|... - gi\|50414924\|gb\|AAH77832.1\| Unknown (protein for MGC:80511) [Xenopus laevis], gi\|215539482\|gb\|AAI7003...	180.0	[0..1]	[169..38]
gi\|38156576, gi\|... - gi\|38156576\|gb\|AAR12910.1\| nuclear transcription factor-Y B subunit 3 [Bufo gargarizans], gi\|3815657...	179.0	[0..1]	[169..38]
NFYB_CHICK - Nuclear transcription factor Y subunit beta OS=Gallus gallus GN=NFYB PE=2 SV=2	178.0	[0..1]	[169..37]
gi\|60653441 - gi\|60653441\|gb\|AAX29415.1\| nuclear transcription factor Y beta [synthetic construct]	177.0	[0..1]	[169..39]
gi\|105492, gi\|35050 - gi\|35050\|emb\|CAA42230.1\| CAAT-box DNA binding protein subunit B (NF-YB) [Homo sapiens], gi\|105492\|pi... gi\|109098520, gi... - gi\|109098520\|ref\|XP_001097495.1\| PREDICTED: similar to Nuclear transcription factor Y subunit beta (...	176.0	[0..1]	[169..37]
ENSMMUT000000317... - null, null NFYB - nuclear transcription factor Y, beta ENSCJAT00000028469 - null gi\|123993257, gi... - gi\|60656481\|gb\|AAX32804.1\| nuclear transcription factor Y beta [synthetic construct], gi\|208966894\|d...	176.0	[0..1]	[169..39]
gi\|73977777 - gi\|73977777\|ref\|XP_532675.2\| PREDICTED: similar to nuclear transcription factor-Y beta isoform 1 [Ca...	176.0	[0..1]	[169..39]
NFYB_HORSE - Nuclear transcription factor Y subunit beta OS=Equus caballus GN=NFYB PE=2 SV=1	176.0	[0..1]	[169..39]

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Predicted Domain #1

Region A:
Residues: [1-183]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNPQEELLP PSAEDDELTL PRASINKIIK ELVPTVRVAN ESRELILNCC SEFIHLISSE  60
   61 ANEVCNMRNK KTINAEHVLE ALERLGFHDY KQEAEAVLHD CKEVAAKRRR QSTRLENLGI 120
  121 PEEELLRQQQ ELFAKAREEQ AREEQQQWMS MQAAAMVQRP PLADGSVASK PSEDDDDDDD 180
  181 DDY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.30103
Match:	1jfiB
Description:	Negative cofactor 2, NC2, beta chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	6.43582244485566	bayes_pls_golite062009
DNA binding	4.49118409263799	bayes_pls_golite062009
nucleic acid binding	4.35201412176948	bayes_pls_golite062009
transcription regulator activity	4.08606081850613	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.28941584139552	bayes_pls_golite062009
binding	3.27510691458843	bayes_pls_golite062009
transcription activator activity	2.58408368884371	bayes_pls_golite062009
transcription factor activity	2.51581622888695	bayes_pls_golite062009
transcription repressor activity	2.3574713307436	bayes_pls_golite062009
protein binding	2.1291876005999	bayes_pls_golite062009
transcription initiation factor activity	1.57176056919918	bayes_pls_golite062009
transcription corepressor activity	1.30859203490073	bayes_pls_golite062009
sequence-specific DNA binding	1.18653213156155	bayes_pls_golite062009
transcription factor binding	1.15204005455906	bayes_pls_golite062009
transcription coactivator activity	1.1297723528047	bayes_pls_golite062009
transcription cofactor activity	1.01502031330902	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: