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View Structure Prediction Details

Protein: CG6523-PA
Organism: Drosophila melanogaster
Length: 216 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG6523-PA.

Description E-value Query
Range
Subject
Range
gi|89269532 - gi|89269532|emb|CAJ82722.1| thioredoxin-like 2 [Xenopus tropicalis]
149.0 [0..2] [213..4]
gi|54261493 - gi|54261493|gb|AAH84367.1| LOC495269 protein [Xenopus laevis]
149.0 [0..2] [213..12]
gi|50749993 - gi|50749993|ref|XP_421826.1| PREDICTED: similar to thioredoxin-like [Gallus gallus]
148.0 [0..3] [212..6]
gi|54645670, gi|... - gi|54645670|gb|EAL34408.1| GA19662 [Drosophila pseudoobscura pseudoobscura], gi|125987153|ref|XP_001...
gi|125987153|ref... - GA19662-PA [Drosophila pseudoobscura], GA19662 [Drosophila pseudoobscura pseudoobscura]
147.0 [0..1] [216..1]
gi|109090971 - gi|109090971|ref|XP_001090479.1| PREDICTED: thioredoxin-like isoform 2 [Macaca mulatta]
146.0 [0..6] [213..16]
gi|73999010 - gi|73999010|ref|XP_535061.2| PREDICTED: similar to Thioredoxin-like 2 protein (PKC-interacting cousi...
146.0 [0..8] [213..16]
GLRX3_MOUSE - Glutaredoxin-3 OS=Mus musculus GN=Glrx3 PE=1 SV=1
145.0 [0..8] [213..20]
GLRX3_RAT - Glutaredoxin-3 OS=Rattus norvegicus GN=Glrx3 PE=1 SV=2
145.0 [0..8] [213..20]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVVNVSAAE EYQKYINADK TTVALFAAEW AEQCGQVKDA LEELAKITGE KLQFISLNAE  60
   61 QFPEISMKHQ IEAVPTVIFF AKGSAVDRVD GVDIAAISAK SKKLAENA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.045757
Match: 1quwA
Description: Thioredoxin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antioxidant activity 3.66884588063322 bayes_pls_golite062009
peroxidase activity 3.43831566988273 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.43831566988273 bayes_pls_golite062009
glutathione peroxidase activity 2.56524997297011 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 1.8187537496904 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.47769936616412 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
selenium binding 1.1082524159827 bayes_pls_golite062009
binding 1.05954762746883 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
transcription regulator activity 0.26464693774353 bayes_pls_golite062009
protein binding 0.034515546627104 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [109-216]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSAAATGQTL EERLKALINT APLMIFMKGD RNGPRCGFSK QLIGIVNETN LPYETFDILG  60
   61 DEEVRQGLKT YSDWPTYPQV YVKGELIGGL DIIKELLANN ELESTLKG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.30103
Match: 1wikA
Description: Solution Structure of the PICOT homology 2 domain of the mouse PKC-interacting cousin of thioredoxin protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antioxidant activity 3.66884588063322 bayes_pls_golite062009
peroxidase activity 3.43831566988273 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.43831566988273 bayes_pls_golite062009
glutathione peroxidase activity 2.56524997297011 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 1.8187537496904 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.47769936616412 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
selenium binding 1.1082524159827 bayes_pls_golite062009
binding 1.05954762746883 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
transcription regulator activity 0.26464693774353 bayes_pls_golite062009
protein binding 0.034515546627104 bayes_pls_golite062009

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