YRC Public Data Repository - Protein Structure Prediction

Protein:	Prosalpha6T-PA
Organism:	Drosophila melanogaster
Length:	289 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Prosalpha6T-PA.

Description	E-value	Query Range	Subject Range
AGAP010253-PA - 20S proteasome subunit alpha 6\|protein_coding\|3R:51664738:51665706:-1\|gene:AGAP010253 gi\|116118542, gi... - gi\|119114702\|ref\|XP_319444.3\| AGAP010253-PA [Anopheles gambiae str. PEST], gi\|116118542\|gb\|EAA13963....	266.0	[0..1]	[279..1]
gi\|157108440, gi... - gi\|157108440\|ref\|XP_001650228.1\| proteasome subunit alpha type [Aedes aegypti], gi\|108868538\|gb\|EAT3...	257.0	[0..1]	[274..1]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p... PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1	251.0	[0..3]	[232..7]
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	251.0	[0..3]	[232..7]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	250.0	[0..3]	[232..7]
gi\|114636649 - gi\|114636649\|ref\|XP_508298.2\| PREDICTED: similar to Proteasome subunit alpha type 1 (Proteasome comp...	250.0	[0..1]	[262..104]
gi\|109107255 - gi\|109107255\|ref\|XP_001089332.1\| PREDICTED: similar to Proteasome subunit alpha type 1 (Proteasome c...	250.0	[0..1]	[262..109]
gi\|73988867 - gi\|73988867\|ref\|XP_534070.2\| PREDICTED: similar to Proteasome subunit alpha type 1 (Proteasome compo...	249.0	[0..1]	[262..106]
gi\|22947842 - gi\|22947842\|gb\|AAN07899.1\| 20S proteasome alpha 6 subunit [Nicotiana benthamiana]	248.0	[0..1]	[236..1]

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Predicted Domain #1

Region A:
Residues: [1-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRNQYDNDT TTWSPQGRLF QVEYAMEAVK QGAATVGLKG TDYAVLAALC RTSKDTNTLQ  60
   61 RKIMPVDDHV GMSIAGLTAD ARVVCQYMRT ECMAYRHSYN AEFPVRRLVS NLGNKLQTTT 120
  121 QRYDRRPYGV GLLVAGYDEQ GPHIYQVMPT ANVLNCKAMA IGSRSQSART YLERNMESFE 180
  181 DCDMDELICH AIQAIRGSLG SDDVENLTIN VAIVGKDVPF KMFTEAENQK YVKLVKAMDP 240
  241 PLEADHDPLS EEGMSDDDMT DHGPSSSGVP PNDTSDMETT ASTGGSDAH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.69897
Match:	1iruF
Description:	Proteasome alpha subunit (non-catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
binding	1.75265921676176	bayes_pls_golite062009
nucleic acid binding	1.39216781236247	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: