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View Structure Prediction Details

Protein: p120ctn-PA
Organism: Drosophila melanogaster
Length: 781 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for p120ctn-PA.

Description E-value Query
Range
Subject
Range
gi|6959880 - gi|6959880|gb|AAF33245.1|AF220496_1 arm repeat protein [Drosophila melanogaster]
522.0 [0..1] [781..1]

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Predicted Domain #1
Region A:
Residues: [1-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEARSLKHSL IGLNMNSTHI NMDLSLTHEP ANMQSQFGSF QNYDQFSAAG YSSTPLYITK  60
   61 PTGVGAITKV APHCSQNKIE TNSTDNSIPD IENHPLATTV RYVQAGQYED TSEYGVAGLT 120
  121 CGIDSEYTAE AVVPYCYTSD ANYTGIQNTT SSIKPFSGRP FNDNINGAEA VADSQCRTFK 180
  181 SSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.69897
Match: 1ejlI
Description: Importin alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [184-626]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFKLPQFAMS SINTVPQRLE EKDDYIEGSE NDICSTMRWR DPNLSEVISF LSNPSSAIKA  60
   61 NAAAYLQHLC YMDDPNKQRT RSLGGIPPLV RLLSYDSPEI HKNACGALRN LSYGRQNDEN 120
  121 KRGIKNAGGI AALVHLLCRS QETEVKELVT GVLWNMSSCE DLKRSIIDEA LVAVVCSVIK 180
  181 PHSGWDAVCC GETCFSTVFR NASGVLRNVS SAGEHARGCL RNCEHLVECL LYVVRTSIEK 240
  241 NNIGNKTVEN CVCILRNLSY RCQEVDDPNY DKHPFITPER VIPSSSKGEN LGCFGTNKKK 300
  301 KEANNSDALN EYNISADYSK SSVTYNKLNK GYEQLWQPEV VQYYLSLLQS CSNPETLEAA 360
  361 AGAIQNLSAC YWQPSIDIRA TVRKEKGLPI LVELLRMEVD RVVCAVATAL RNLAIDQRNK 420
  421 ELIGKYAMRD LVQKLPSGNV QHD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.69897
Match: 1gw5B
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.99013774955562 bayes_pls_golite062009
cell adhesion molecule binding 1.83254788740042 bayes_pls_golite062009
protein binding 1.75981610748679 bayes_pls_golite062009
RPTP-like protein binding 1.38347756516661 bayes_pls_golite062009
cadherin binding 0.1400783779596 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [627-696]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNTSDDTITA VLATINEVIK KNPEFSRSLL DSGGIDRLMN ITKRKEKYTS CVLKFASQVL  60
   61 YTMWQHNELR 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.221849
Match: 1xm9A
Description: Structure of the armadillo repeat domain of plakophilin 1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [697-781]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVYKKNGWKE QDFVSKHFTA HNTPPSSPNN VNNTLNRPMA SQGRTRYEDR TIQRGTSTLY  60
   61 SANDSSGAVM SNESAMLSEM VRKQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle