YRC Public Data Repository - Protein Structure Prediction

Protein:	PHB_RAT
Organism:	Rattus norvegicus
Length:	272 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHB_RAT.

Description	E-value	Query Range	Subject Range
PHB_CHICK - Prohibitin OS=Gallus gallus GN=PHB PE=1 SV=1	243.0	[0..1]	[272..1]
gi\|89272030, gi\|... - gi\|89272810\|emb\|CAJ82042.1\| prohibitin [Xenopus tropicalis], gi\|89272030\|emb\|CAJ83243.1\| prohibitin ...	241.0	[0..1]	[272..1]
gi\|74181431, gi\|... - gi\|74185218\|dbj\|BAE30089.1\| unnamed protein product [Mus musculus], gi\|74181431\|dbj\|BAE29988.1\| unna...	238.0	[0..1]	[272..1]
gi\|61362617, gi\|... - gi\|61362624\|gb\|AAX42254.1\| prohibitin [synthetic construct], gi\|61362617\|gb\|AAX42253.1\| prohibitin [... HGNC:8912\|MIM:17... - null PHB - prohibitin PHB_BOVIN - Prohibitin OS=Bos taurus GN=PHB PE=2 SV=1 gi\|158906128, gi... - gi\|160333845\|ref\|NP_001103918.1\| prohibitin [Felis catus], gi\|158906128\|gb\|ABW82705.1\| prohibitin [F... gi\|158442066, gi... - gi\|158819069\|ref\|NP_001103649.1\| prohibitin [Canis lupus familiaris], gi\|158442066\|gb\|ABW38778.1\| pr... gi\|109114258, gi... - gi\|109114260\|ref\|XP_001093569.1\| PREDICTED: similar to prohibitin isoform 7 [Macaca mulatta], gi\|109... ENSCJAT00000014086 - null gi\|114666273, gi... - gi\|55646807\|ref\|XP_511949.1\| PREDICTED: prohibitin isoform 7 [Pan troglodytes], gi\|114666277\|ref\|XP_...	237.0	[0..1]	[272..1]
gi\|60829530 - gi\|60829530\|gb\|AAX36882.1\| prohibitin [synthetic construct]	237.0	[0..1]	[272..1]
gi\|32766612, gi\|... - gi\|32766612\|gb\|AAH54971.1\| MGC64447 protein [Xenopus laevis], gi\|148230088\|ref\|NP_001079819.1\| hypot...	236.0	[0..1]	[272..1]
gi\|67970515 - gi\|67970515\|dbj\|BAE01600.1\| unnamed protein product [Macaca fascicularis]	236.0	[0..1]	[272..1]

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Predicted Domain #1

Region A:
Residues: [1-197]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW  60
   61 VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIYTSI GEDYDERVLP 120
  121 SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT 180
  181 EAVEAKQVAQ QEAERAR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.39794
Match:	1winA
Description:	Solution Structure of the Band 7 Domain of the mouse Flotillin 2 Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.10215477176861	bayes_pls_golite062009
protein binding	0.769979871341236	bayes_pls_golite062009
structural molecule activity	0.591437172549816	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [198-272]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVVEKAEQQK KAAIISAEGD SKAAELIANS LATAGDGLIE LRKLEAAEDI AYQLSRSRNI  60
   61 TYLPAGQSVL LQLPQ

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: