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View Structure Prediction Details

Protein: BOK_RAT
Organism: Rattus norvegicus
Length: 213 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BOK_RAT.

Description E-value Query
Range
Subject
Range
gi|6456033 - gi|6456033|gb|AAF09129.1|AF089746_1 Bcl-2 related ovarian killer [Homo sapiens]
254.0 [0..1] [213..1]
BOK_CHICK - Bcl-2-related ovarian killer protein OS=Gallus gallus GN=BOK PE=2 SV=1
251.0 [0..1] [213..1]
gi|60653073, gi|... - gi|60653075|gb|AAX29232.1| BCL2-related ovarian killer [synthetic construct], gi|60653073|gb|AAX2923...
243.0 [0..1] [213..1]
gi|76637845, gi|... - gi|76637845|ref|XP_581033.2| PREDICTED: similar to BCL-2-related ovarian killer protein isoform 1 [B...
241.0 [0..1] [213..1]
BOKA_DANRE - Bcl-2-related ovarian killer protein homolog A OS=Danio rerio GN=boka PE=2 SV=1
218.0 [0..1] [213..1]
gi|47212535 - gi|47212535|emb|CAF90551.1| unnamed protein product [Tetraodon nigroviridis]
208.0 [0..1] [213..1]

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Predicted Domain #1
Region A:
Residues: [1-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERASPAP  60
   61 GGRLAEVCTV LLRLGDELEQ IRPSVYRNVA RQLHIPLQSE PVVTDAFLAV AGHIFSAGIT 120
  121 WGKVVSLYSV AAGLAVDCVR QAQPAMVHAL VDCLGEFVRK TLATWLRRRG GWTDVLKCVV 180
  181 STDPGFRSHW LVATLCSFGR FLKAAFFLLL PER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.69897
Match: 1yswA
Description: Solution structure of the anti-apoptotic protein Bcl-2 complexed with an acyl-sulfonamide-based ligand
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.78803636113333 bayes_pls_golite062009
binding 2.12358089265543 bayes_pls_golite062009
protein dimerization activity 1.64504453561047 bayes_pls_golite062009
protein heterodimerization activity 1.52306670675388 bayes_pls_golite062009
death domain binding 0.807539351618739 bayes_pls_golite062009
identical protein binding 0.488482699265135 bayes_pls_golite062009
BH3 domain binding 0.351738412090861 bayes_pls_golite062009
BH domain binding 0.173539163685055 bayes_pls_golite062009
caspase regulator activity 0.0685275773265202 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle