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View Structure Prediction Details

Protein: MITF_RAT
Organism: Rattus norvegicus
Length: 110 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MITF_RAT.

Description E-value Query
Range
Subject
Range
gi|109124486 - gi|109124486|ref|XP_001111345.1| PREDICTED: similar to LISCH protein isoform 1 [Macaca mulatta]
127.0 [0..4] [108..595]
gi|34539034 - gi|34539034|gb|AAQ74413.1| microphthalmia-associated transcription factor isoform H [Canis familiari...
121.0 [0..1] [110..174]
USF2 - upstream transcription factor 2, c-fos interacting
120.0 [0..4] [108..219]
gi|94379911, gi|... - gi|94379911|ref|XP_001001413.1| PREDICTED: similar to upstream transcription factor 2 [Mus musculus]...
120.0 [0..4] [108..246]
gi|114587816 - gi|114587816|ref|XP_001138431.1| PREDICTED: microphthalmia-associated transcription factor isoform 4...
119.0 [0..1] [110..185]

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Predicted Domain #1
Region A:
Residues: [1-110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTACIFPTES EARALAKERQ KKDNHNLIER RRRFNINDRI KELGTLIPKS NDPDMRWNKG  60
   61 TILKASVDYI RKLQREQQRA KDLENRQKKL EHANRHLLLR VQELEMQARA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.09691
Match: 1r05A
Description: Solution Structure of Max B-HLH-LZ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
promoter binding 0.8576109846276 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle