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View Structure Prediction Details

Protein: TIMP2_RAT
Organism: Rattus norvegicus
Length: 220 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIMP2_RAT.

Description E-value Query
Range
Subject
Range
gi|74354677, gi|... - gi|75832065|ref|NP_776897.2| TIMP metallopeptidase inhibitor 2 [Bos taurus], gi|74354677|gb|AAI02711...
370.0 [0..1] [220..1]
gi|26328599 - gi|26328599|dbj|BAC28038.1| unnamed protein product [Mus musculus]
353.0 [0..1] [220..1]
TIMP2_CANLF - Metalloproteinase inhibitor 2 OS=Canis lupus familiaris GN=TIMP2 PE=2 SV=2
350.0 [0..1] [220..1]
TIMP2 - TIMP metallopeptidase inhibitor 2
349.0 [0..23] [220..23]
gi|631854, gi|540205 - pir||S45683 metalloproteinase inhibitor 2 precursor - rat, gi|540205|gb|AAA21553.1| tissue inhibito...
348.0 [0..23] [220..23]
TIMP2_CAVPO - Metalloproteinase inhibitor 2 OS=Cavia porcellus GN=TIMP2 PE=2 SV=1
347.0 [0..24] [220..24]

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Predicted Domain #1
Region A:
Residues: [1-220]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAAARSLRL ALGLLLLATL LRPADACSCS PVHPQQAFCN ADVVIRAKAV SEKEVDSGND  60
   61 IYGNPIKRIQ YEIKQIKMFK GPDKDIEFIY TAPSSAVCGV SLDVGGKKEY LIAGKAEGDG 120
  121 KMHITLCDFI VPWDTLSITQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE 180
  181 KSINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.221849
Match: 1br9A
Description: HUMAN TISSUE INHIBITOR OF METALLOPROTEINASE-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
metalloendopeptidase inhibitor activity 7.17434748400899 bayes_pls_golite062009
metalloenzyme regulator activity 7.17434748400899 bayes_pls_golite062009
metalloenzyme inhibitor activity 7.17434748400899 bayes_pls_golite062009
peptidase inhibitor activity 3.93668549411033 bayes_pls_golite062009
endopeptidase inhibitor activity 3.90361447859652 bayes_pls_golite062009
enzyme regulator activity 2.05189175806105 bayes_pls_golite062009
protein binding 2.04187591727985 bayes_pls_golite062009
receptor binding 1.79096938850925 bayes_pls_golite062009
cytokine activity 1.72828967672993 bayes_pls_golite062009
binding 1.57363735103063 bayes_pls_golite062009
enzyme inhibitor activity 1.54714635439345 bayes_pls_golite062009
G-protein-coupled receptor binding 0.6932827058439 bayes_pls_golite062009
chemokine activity 0.59253057522745 bayes_pls_golite062009
chemokine receptor binding 0.59253057522745 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle