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View Structure Prediction Details

Protein: gi|123982672, gi...
Organism: synthetic construct
Length: 315 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|123982672, gi....

Description E-value Query
Range
Subject
Range
gi|61371853, gi|... - gi|61371853|gb|AAX43743.1| eukaryotic translation initiation factor 2 subunit 1 alpha [synthetic con...
7.0E-73 [1..315] [1..315]
IF2A_PONAB - Eukaryotic translation initiation factor 2 subunit 1 OS=Pongo abelii GN=EIF2S1 PE=2 SV=1
gi|55733490 - gi|55733490|emb|CAH93423.1| hypothetical protein [Pongo abelii]
1.0E-72 [1..315] [1..315]
IF2A_XENTR - Eukaryotic translation initiation factor 2 subunit 1 OS=Xenopus tropicalis GN=eif2s1 PE=2 SV=1
2.0E-72 [1..315] [1..315]
IF2A_XENLA - Eukaryotic translation initiation factor 2 subunit 1 OS=Xenopus laevis GN=eif2s1 PE=2 SV=1
3.0E-72 [1..315] [1..315]
tr|G1T2G4|G1T2G4... - pep:known chromosome:oryCun2:20:4901008:4927649:-1 gene:ENSOCUG00000012023 transcript:ENSOCUT0000001...
gi|194038445, gi... - gi|194038445|ref|XP_001928374.1| PREDICTED: similar to eukaryotic translation initiation factor 2, s...
IF2A_MOUSE - Eukaryotic translation initiation factor 2 subunit 1 OS=Mus musculus GN=Eif2s1 PE=1 SV=3
IF2A_BOVIN - Eukaryotic translation initiation factor 2 subunit 1 OS=Bos taurus GN=EIF2S1 PE=2 SV=2
IF2A_RAT - Eukaryotic translation initiation factor 2 subunit 1 OS=Rattus norvegicus GN=Eif2s1 PE=1 SV=2
gi|57090227 - gi|57090227|ref|XP_537485.1| PREDICTED: similar to Eukaryotic translation initiation factor 2 subuni...
3.0E-72 [1..315] [1..315]
gi|157423429, gi... - gi|7739753|gb|AAF68997.1|AF257517_1 eIF2 alpha subunit [Danio rerio], gi|41351478|gb|AAH65879.1| Euk...
1.0E-71 [1..315] [1..315]
gi|47224559 - gi|47224559|emb|CAG03543.1| unnamed protein product [Tetraodon nigroviridis]
4.0E-71 [1..315] [1..315]
gi|39975863, gi|... - gi|39975863|ref|XP_369322.1| hypothetical protein MG06142.4 [Magnaporthe grisea 70-15], gb|EAA53014....
4.0E-71 [1..311] [1..304]
gi|185134951, gi... - gi|185134951|ref|NP_001117768.1| eukaryotic initiation factor 2 alpha subunit [Oncorhynchus mykiss],...
6.0E-71 [1..315] [1..315]

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Predicted Domain #1
Region A:
Residues: [1-315]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN  60
   61 KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED KFTKSKTVYS ILRHVAEVLE 120
  121 YTKDEQLESL FQRTAWVFDD KYKRPGYGAY DAFKHAVSDP SILDSLDLNE DEREVLINNI 180
  181 NRRLTPQAVK IRADIEVACY GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT 240
  241 TLERTEGLSV LSQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQM ERLERENAEV 300
  301 DGDDDAEEME AKAED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.522879
Match: 1q8kA
Description: Solution structure of alpha subunit of human eIF2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 10.6089165352091 bayes_pls_golite062009
structural constituent of ribosome 6.60650180781768 bayes_pls_golite062009
translation regulator activity 6.15562485158748 bayes_pls_golite062009
structural molecule activity 6.0174879876147 bayes_pls_golite062009
DNA binding 3.38561002225202 bayes_pls_golite062009
nucleic acid binding 2.60981339834849 bayes_pls_golite062009
structure-specific DNA binding 2.50756546575713 bayes_pls_golite062009
single-stranded DNA binding 2.36609416429058 bayes_pls_golite062009
binding 2.263388192549 bayes_pls_golite062009
RNA binding 1.76502371106766 bayes_pls_golite062009
transcription regulator activity 1.69669059514663 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.60662288414996 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.33094846641297 bayes_pls_golite062009
transferase activity 0.945564658432858 bayes_pls_golite062009
mRNA binding 0.883475899526061 bayes_pls_golite062009
transcription factor activity 0.859071050218437 bayes_pls_golite062009
sequence-specific DNA binding 0.77755643935497 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.474251377131502 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.47336621289748 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.47336621289748 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.448368263932591 bayes_pls_golite062009
exoribonuclease activity 0.40142383001471 bayes_pls_golite062009
3'-5' exonuclease activity 0.33985916978927 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.16147560902991 bayes_pls_golite062009
protein binding 0.152645195799531 bayes_pls_golite062009

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