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View Structure Prediction Details

Protein: RHOX5_MOUSE
Organism: Mus musculus
Length: 210 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RHOX5_MOUSE.

Description E-value Query
Range
Subject
Range
gi|6003605 - gi|6003605|gb|AAF00509.1| homeobox protein [Mastomys sp.]
161.0 [0..1] [210..1]
gi|6003596 - gi|6003596|gb|AAF00507.1| homeobox protein [Mus caroli]
136.0 [0..1] [210..1]
gi|786328 - gi|786328|gb|AAB32671.1| Pax-6 [Rattus sp.]
gi|480038, gi|446399 - gi|480038|pir||S36166 paired box transcription factor Pax-6 - rat (fragment), gi|446399|prf||1911405...
135.0 [0..5] [210..25]
gi|33440489 - gi|33440489|gb|AAH56204.1| Reproductive homeobox 5 [Mus musculus]
133.0 [0..1] [210..1]
gi|6003617 - gi|6003617|gb|AAF00512.1| homeobox protein [Mus saxicola]
132.0 [0..1] [210..1]
gi|6003613 - gi|6003613|gb|AAF00511.1| homeobox protein [Mus pahari]
127.0 [0..1] [210..1]
gi|6003621 - gi|6003621|gb|AAF00513.1| homeobox protein [Stochomys longicaudatus]
126.0 [0..1] [210..1]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAEGSSRKV TRLLRLGVKE DSEEQHDVKA EAFFQAGEGR DEQGAQGQPG VGAVGTEGEG  60
   61 EELNGGKGHF GPGAPGPMGD GDKDSGTRAG GVEQEQNEPV A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [102-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGTESQENGN PGGRQMPLQG SRFAQHRLRE LESILQRTNS FDVPREDLDR LMDACVSRVQ  60
   61 NWFKIRRAAA RRTRRRATPV PEHFRGTFEC PACRGVRWGE RCPFATPRF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.154902
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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