YRC Public Data Repository - Protein Structure Prediction

Protein:	ORC6_MOUSE
Organism:	Mus musculus
Length:	262 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ORC6_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|255069719, gi... - gi\|51873847\|gb\|AAH80739.1\| Origin recognition complex, subunit 6-like (S. cerevisiae) [Mus musculus]...	384.0	[0..1]	[262..1]
gi\|27658770, gi\|... - gi\|76096324\|ref\|NP_001028862.1\| origin recognition complex, subunit 6 like [Rattus norvegicus], gi\|7...	378.0	[0..1]	[262..1]
HGNC:17151\|MIM:6... - recognition complex, subunit 6 like (yeast) gi\|117646404, gi... - gi\|117646818\|emb\|CAL37524.1\| hypothetical protein [synthetic construct], gi\|117646404\|emb\|CAL38669.1... ORC6L - origin recognition complex, subunit 6 like (yeast)	360.0	[0..1]	[262..1]
gi\|114662327 - gi\|114662327\|ref\|XP_001161833.1\| PREDICTED: origin recognition complex subunit 6 isoform 4 [Pan trog...	358.0	[0..1]	[262..1]
gi\|109128387 - gi\|109128387\|ref\|XP_001113625.1\| PREDICTED: similar to origin recognition complex subunit 6 [Macaca ...	354.0	[0..1]	[262..1]
ORC6_BOVIN - Origin recognition complex subunit 6 OS=Bos taurus GN=ORC6 PE=2 SV=1	337.0	[0..1]	[262..1]
gi\|73977476 - gi\|73977476\|ref\|XP_539609.2\| PREDICTED: similar to origin recognition complex subunit 6 [Canis famil...	308.0	[0..1]	[262..1]
gi\|33989468, gi\|... - gi\|47086695\|ref\|NP_997836.1\| origin recognition complex, subunit 6 homolog-like [Danio rerio], gi\|41...	296.0	[0..1]	[258..1]
Orc6-PA - The gene Origin recognition complex subunit 6 is referred to in FlyBase by the symbol Dmel\Orc6 (CG1... gi\|220957662, gi... - gi\|220957662\|gb\|ACL91374.1\| Orc6-PA [synthetic construct], gi\|220948902\|gb\|ACL86994.1\| CG1584-PA [sy...	291.0	[0..5]	[262..4]

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Predicted Domain #1

Region A:
Residues: [1-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESELVRRLA PRLGLAEPSV LRKAEEFLRL SKVKCVSLSA RSSETSNAVI CLDLAASCRK  60
   61 CPLDRAYLIR LSGLNKMMYQ SCLKSFECLL GLNSNVGIRD LAVQFSCTEA VNLAAEILQS 120
  121 YKSGLPETQR ADLDLSRPLF TTAALLSACK ILKIKVDKTK MITTSGVKKA ILDRLCKQLE 180
  181 KIGQQINRDS ADLARPALKR KKPEFSPTLK KKEPGLEPPA KEIEVIETLH KLPKDEDLTQ 240
  241 DYEEWKRKIL ENAAKAQTAT AE

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.39
Match:	1tfbA
Description:	NMR STUDIES OF HUMAN GENERAL TRANSCRIPTION FACTOR TFIIB: DYNAMICS AND INTERACTION WITH VP16 ACTIVATION DOMAIN, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.75688185850223	bayes_pls_golite062009
binding	2.37916921859542	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.37399236069363	bayes_pls_golite062009
nucleic acid binding	2.06743451505655	bayes_pls_golite062009
DNA binding	1.95321993038755	bayes_pls_golite062009
transcription repressor activity	1.41828738664896	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	1.41497909264171	bayes_pls_golite062009
protein binding	1.37207701115974	bayes_pls_golite062009
transcription factor activity	1.22628491144894	bayes_pls_golite062009
protein kinase regulator activity	1.21941169140389	bayes_pls_golite062009
kinase regulator activity	1.18590233040331	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.962670695182671	bayes_pls_golite062009
transcription factor binding	0.655253705928308	bayes_pls_golite062009
enzyme regulator activity	0.461517963237846	bayes_pls_golite062009
transcription coactivator activity	0.0843751392410543	bayes_pls_golite062009
transcription activator activity	0.0606514459376675	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: