YRC Public Data Repository - Protein Structure Prediction

Protein:	IAH1_MOUSE
Organism:	Mus musculus
Length:	249 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IAH1_MOUSE.

Description	E-value	Query Range	Subject Range
IAH1_RAT - Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Rattus norvegicus GN=Iah1 PE=2 SV=2	235.0	[0..1]	[249..1]
gi\|109101965 - gi\|109101965\|ref\|XP_001084501.1\| PREDICTED: hypothetical protein isoform 2 [Macaca mulatta]	228.0	[0..1]	[249..1]
gi\|114576028 - gi\|114576028\|ref\|XP_001155422.1\| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes] IAH1 - isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)	228.0	[0..1]	[249..1]
gi\|73980321 - gi\|73980321\|ref\|XP_852049.1\| PREDICTED: hypothetical protein XP_846956 [Canis familiaris]	228.0	[0..1]	[249..1]
IAH1_BOVIN - Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Bos taurus GN=IAH1 PE=2 SV=1	228.0	[0..1]	[249..1]
gi\|50745011 - gi\|50745011\|ref\|XP_419943.1\| PREDICTED: similar to hypothetical protein 4833421E05Rik [Gallus gallus...	200.0	[0..1]	[245..67]
gi\|114576030 - gi\|114576030\|ref\|XP_001155356.1\| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes] gi\|119621391 - gi\|119621391\|gb\|EAX00986.1\| hCG1685787, isoform CRA_c [Homo sapiens]	197.0	[0..26]	[249..1]
gi\|63101440 - gi\|63101440\|gb\|AAH95279.1\| Iah1 protein [Danio rerio]	188.0	[0..3]	[246..18]

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Predicted Domain #1

Region A:
Residues: [1-249]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLCERAASG SALLWPRVLL FGDSITQFSF QQGGWGSLLA DRLVRKCDVL NRGFSGYNTR  60
   61 WAKIILPRLI RKGPGMENPV AVTIFFGAND SSLKDENPKQ HVPLDEYSAN LRDMVQYLRS 120
  121 VDVPRERVIL ITPPPLCEAA WEKECVLKGC KLNRLNSVVG EYANACLQVA RDCGTDVLDL 180
  181 WTLMQKDSQD FSSYLSDGLH LSPMGNEFLF LNLCPLLDKK VSSLPWLLPY WKDVEEAKPE 240
  241 LSLLGDGDY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.30103
Match:	1fxwF
Description:	Platelet-activating factor acetylhydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.15974340242656	bayes_pls_golite062009
hydrolase activity	0.755660272658182	bayes_pls_golite062009
binding	0.723787843954977	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.39017969987234	bayes_pls_golite062009
protein binding	0.289427729451854	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: