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View Structure Prediction Details

Protein: NTF3_MOUSE
Organism: Mus musculus
Length: 258 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTF3_MOUSE.

Description E-value Query
Range
Subject
Range
gi|109095185 - gi|109095185|ref|XP_001118191.1| PREDICTED: neurotrophin 3 [Macaca mulatta]
409.0 [0..1] [258..71]
NTF3_RAT - Neurotrophin-3 OS=Rattus norvegicus GN=Ntf3 PE=2 SV=1
408.0 [0..1] [258..1]
gi|74209040 - gi|74209040|dbj|BAE21247.1| unnamed protein product [Mus musculus]
408.0 [0..1] [258..14]
gi|51949752 - gi|51949752|gb|AAU14794.1| neurotrophin 3 precursor [synthetic construct]
406.0 [0..1] [258..1]
gi|114642998 - gi|114642998|ref|XP_522331.2| PREDICTED: neurotrophin 3 [Pan troglodytes]
406.0 [0..1] [258..1]
NTF3 - neurotrophin 3
gi|60818243, gi|... - gi|60818243|gb|AAX36456.1| neurotrophin 3 [synthetic construct], gi|208968625|dbj|BAG74151.1| neurot...
403.0 [0..1] [258..1]
gi|73997470 - gi|73997470|ref|XP_543858.2| PREDICTED: similar to Neurotrophin-3 precursor (NT-3) (Neurotrophic fac...
401.0 [0..1] [258..1]
NTF3_FELCA - Neurotrophin-3 OS=Felis catus GN=NTF3 PE=3 SV=1
398.0 [0..1] [258..1]
NTF3_CHICK - Neurotrophin-3 OS=Gallus gallus GN=NTF3 PE=2 SV=2
390.0 [0..1] [258..1]

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Predicted Domain #1
Region A:
Residues: [1-134]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ  60
   61 STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 120
  121 EDYVGNPVVA NRTS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [135-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRRKRYAEHK SHRGEYSVCD SESLWVTDKS SAIDIRGHQV TVLGEIKTGN SPVKQYFYET  60
   61 RCKEARPVKN GCRGIDDKHW NSQCKTSQTY VRALTSENNK LVGWRWIRID TSCVCALSRK 120
  121 IGRT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.0
Match: 1b8kA
Description: Neurotrophin 3, NT3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
growth factor activity 4.74498867224238 bayes_pls_golite062009
receptor binding 4.70889547404918 bayes_pls_golite062009
neurotrophin TRKB receptor binding 4.62719877337644 bayes_pls_golite062009
neurotrophin TRK receptor binding 4.62719877337644 bayes_pls_golite062009
neurotrophin p75 receptor binding 4.09253117188665 bayes_pls_golite062009
cytokine activity 3.61376517935324 bayes_pls_golite062009
receptor serine/threonine kinase binding 3.60727548920187 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 3.46872954776606 bayes_pls_golite062009
transforming growth factor beta receptor binding 3.46872954776606 bayes_pls_golite062009
protein binding 3.41839891062651 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 3.16494996397951 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 3.0813162230094 bayes_pls_golite062009
cell surface binding 2.9725198156666 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 2.85718611591787 bayes_pls_golite062009
binding 2.85157432803513 bayes_pls_golite062009
platelet-derived growth factor receptor binding 2.5098842713893 bayes_pls_golite062009
glycosaminoglycan binding 2.49731836866959 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 2.3694685471074 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 2.18218102861024 bayes_pls_golite062009
growth factor binding 2.15782167869238 bayes_pls_golite062009
heparin binding 2.11784489374422 bayes_pls_golite062009
hormone activity 2.10500409590202 bayes_pls_golite062009
protein dimerization activity 1.82426827198541 bayes_pls_golite062009
transcription regulator activity 1.71788348798334 bayes_pls_golite062009
protein homodimerization activity 1.377005150119 bayes_pls_golite062009
molecular transducer activity 1.3285764158511 bayes_pls_golite062009
signal transducer activity 1.3285764158511 bayes_pls_golite062009
identical protein binding 1.18858126900765 bayes_pls_golite062009
platelet-derived growth factor binding 1.18476084022243 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
transcription activator activity 1.12971001221094 bayes_pls_golite062009
collagen binding 1.00551310632663 bayes_pls_golite062009
protein heterodimerization activity 0.97031505698447 bayes_pls_golite062009
morphogen activity 0.91146826241391 bayes_pls_golite062009
pattern binding 0.90497366619649 bayes_pls_golite062009
nerve growth factor binding 0.83909377726083 bayes_pls_golite062009
protein kinase activity 0.81930974773732 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 0.772832351269279 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.461278618625267 bayes_pls_golite062009
kinase activity 0.457160916814967 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.320182329352662 bayes_pls_golite062009
protein serine/threonine kinase activity 0.137002941165399 bayes_pls_golite062009
catalytic activity 0.105223830172599 bayes_pls_golite062009
fibronectin binding 0.0979012997097199 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle