YRC Public Data Repository - Protein Structure Prediction

Protein:	FGF4_MOUSE
Organism:	Mus musculus
Length:	202 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FGF4_MOUSE.

Description	E-value	Query Range	Subject Range
FGF4B_XENLA - Fibroblast growth factor 4B OS=Xenopus laevis GN=fgf4-b PE=2 SV=1	217.0	[0..5]	[202..1]
FGF4 - fibroblast growth factor 4 gi\|225000230, gi... - gi\|225000230\|gb\|AAI72495.1\| Fibroblast growth factor 4 [synthetic construct], gi\|162318992\|gb\|AAI563...	214.0	[0..1]	[202..1]
gi\|109105124 - gi\|109105124\|ref\|XP_001100747.1\| PREDICTED: fibroblast growth factor 4 (heparin secretory transformi... gi\|114639012 - gi\|114639012\|ref\|XP_001173970.1\| PREDICTED: fibroblast growth factor 4 [Pan troglodytes]	212.0	[0..1]	[202..1]
gi\|73983565 - gi\|73983565\|ref\|XP_540801.2\| PREDICTED: similar to Fibroblast growth factor-4 precursor (FGF-4) (Hep...	211.0	[0..22]	[202..22]
gi\|114642913 - gi\|114642913\|ref\|XP_001157123.1\| PREDICTED: fibroblast growth factor 6 [Pan troglodytes]	209.0	[0..3]	[202..14]
gi\|3980190 - gi\|3980190\|emb\|CAA76422.1\| fibroblast growth factor 6-related protein [Oncorhynchus mykiss]	206.0	[0..1]	[202..11]

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Predicted Domain #1

Region A:
Residues: [1-202]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKRGPTTGT LLPRVLLALV VALADRGTAA PNGTRHAELG HGWDGLVARS LARLPVAAQP  60
   61 PQAAVRSGAG DYLLGLKRLR RLYCNVGIGF HLQVLPDGRI GGVHADTRDS LLELSPVQRG 120
  121 VVSIFGVASR FFVAMSSRGK LFGVPFFTDE CKFKEILLPN NYNAYEAYAY PGMFMALSKN 180
  181 GRTKKGNRVS PTMKVTHFLP RL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.522879
Match:	1ijtA
Description:	Fibroblast growth factor 4 (FGF4)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
growth factor activity	5.6790632853895	bayes_pls_golite062009
fibroblast growth factor receptor binding	5.32138222782692	bayes_pls_golite062009
receptor binding	4.8109037277027	bayes_pls_golite062009
cytokine activity	3.23273280319483	bayes_pls_golite062009
protein binding	2.73885234721265	bayes_pls_golite062009
binding	1.9997408351526	bayes_pls_golite062009
heparin binding	1.71092312487163	bayes_pls_golite062009
glycosaminoglycan binding	0.62267092567268	bayes_pls_golite062009
polysaccharide binding	0.55309369051712	bayes_pls_golite062009
pattern binding	0.456311281248659	bayes_pls_golite062009
nerve growth factor receptor binding	0.308245352535379	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: