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View Structure Prediction Details

Protein: HXB7_MOUSE
Organism: Mus musculus
Length: 217 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HXB7_MOUSE.

Description E-value Query
Range
Subject
Range
HXB7_RAT - Homeobox protein Hox-B7 OS=Rattus norvegicus GN=Hoxb7 PE=2 SV=2
162.0 [0..1] [212..1]
gi|61368483, gi|... - gi|61369779|gb|AAX43390.1| homeobox B7 [synthetic construct], gi|61368483|gb|AAX43187.1| homeobox B7...
160.0 [0..1] [207..1]
gi|73966250 - gi|73966250|ref|XP_851221.1| PREDICTED: similar to Homeobox protein Hox-B7 (Hox-2C) (HHO.C1) [Canis ...
160.0 [0..1] [208..1]
HOXB7 - homeobox B7
159.0 [0..1] [207..1]
HXB7_BOVIN - Homeobox protein Hox-B7 OS=Bos taurus GN=HOXB7 PE=2 SV=1
159.0 [0..1] [207..1]
HXB7_MOUSE - Homeobox protein Hox-B7 OS=Mus musculus GN=Hoxb7 PE=2 SV=2
gi|147897801 - gi|147897801|gb|AAI40345.1| Homeo box B7 [synthetic construct]
159.0 [0..1] [208..1]
gi|109114195 - gi|109114195|ref|XP_001088822.1| PREDICTED: homeobox B7 [Macaca mulatta]
157.0 [0..1] [208..1]

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Predicted Domain #1
Region A:
Residues: [1-119]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP FSASVQGLYS  60
   61 GGGAMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDAAKAGGA KEQRDSDLA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [120-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AESNFRIYPW MRSSGPDRKR GRQTYTRYQT LELEKEFHYN RYLTRRRRIE IAHTLCLTER  60
   61 QIKIWFQNRR MKWKKENKTS GPGTTGQDKA EGEEEEEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.221849
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009

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