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View Structure Prediction Details

Protein: XPA_MOUSE
Organism: Mus musculus
Length: 272 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XPA_MOUSE.

Description E-value Query
Range
Subject
Range
gi|84579859, gi|... - gi|84579859|ref|NP_001033770.1| xeroderma pigmentosum, complementation group A [Bos taurus], gi|8375...
332.0 [0..4] [272..2]
gi|34935127, gi|... - gi|34935127|ref|XP_216403.2| PREDICTED: similar to DNA-repair protein complementing XP-A cells homol...
332.0 [0..1] [272..1]
gi|60654147 - gi|60654147|gb|AAX29766.1| xeroderma pigmentosum complementation group A [synthetic construct]
330.0 [0..11] [272..9]
gi|61357324, gi|... - gi|61357324|gb|AAX41371.1| xeroderma pigmentosum complementation group A [synthetic construct], gi|1...
XPA - xeroderma pigmentosum, complementation group A
330.0 [0..11] [272..9]
gi|73971420 - gi|73971420|ref|XP_538745.2| PREDICTED: similar to DNA-repair protein complementing XP-A cells (Xero...
324.0 [0..4] [272..2]

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Predicted Domain #1
Region A:
Residues: [1-62]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATAEEKQTS PEPVAADEPA QLPAAVRASV ERKRQRALML RQARLAARPY PAAAATGGVA  60
   61 SV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [63-272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAAPKMIDTK GGFILEEEEE KHEIGNIVHE PGPVMEFDYT ICEECGKEFM DSYLMNHFDL  60
   61 PTCDSCRDAD DKHKLITKTE AKQEYLLKDC DLEKREPALR FLVKKNPRHS QWGDMKLYLK 120
  121 LQVVKRALEV WGSQEALEDA KEVRQENREK MKQKKFDKKV KELRRAIRSS VWKRETTTHQ 180
  181 HEYGPEENLE DDMYRKTCTL CGHELTYEKM 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.69897
Match: 1xpaA
Description: SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.96409924710655 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
transcription regulator activity 2.22839475692516 bayes_pls_golite062009
DNA binding 2.18702281581791 bayes_pls_golite062009
nucleic acid binding 2.04270847321412 bayes_pls_golite062009
transcription activator activity 1.60639114794515 bayes_pls_golite062009
sequence-specific DNA binding 1.59705128803795 bayes_pls_golite062009
transcription factor activity 1.44182975349714 bayes_pls_golite062009
structure-specific DNA binding 0.610805977602876 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 0.55799224325565 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.51536225088963 bayes_pls_golite062009
transcription factor binding 0.43597775400036 bayes_pls_golite062009
transcription coactivator activity 0.42962641193703 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.37925266318051 bayes_pls_golite062009
double-stranded DNA binding 0.280685154942276 bayes_pls_golite062009
receptor activity 0.230063209127305 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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