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View Structure Prediction Details

Protein: VPS25_MOUSE
Organism: Mus musculus
Length: 176 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS25_MOUSE.

Description E-value Query
Range
Subject
Range
gi|109489035 - gi|109489035|ref|XP_001060127.1| PREDICTED: similar to Vacuolar protein sorting protein 25 (ELL-asso...
306.0 [0..1] [176..186]
gi|73965636 - gi|73965636|ref|XP_849270.1| PREDICTED: similar to Serine/threonine-protein kinase WNK4 (Protein kin...
293.0 [0..1] [176..27]
ENSMMUT000000030... - null, null
CCDS11438.1_1 - null
ENSPTRT00000016956 - null
VPS25 - vacuolar protein sorting 25 homolog (S. cerevisiae)
287.0 [0..1] [176..1]
gi|114579076 - gi|114579076|ref|XP_530480.2| PREDICTED: similar to Vacuolar protein sorting 25 homolog (S. cerevisi...
287.0 [0..1] [176..1]
VPS25_BOVIN - Vacuolar protein-sorting-associated protein 25 OS=Bos taurus GN=VPS25 PE=2 SV=1
286.0 [0..1] [176..1]
gi|47220639 - gi|47220639|emb|CAG06561.1| unnamed protein product [Tetraodon nigroviridis]
286.0 [0..2] [176..1]
gi|45709514 - gi|45709514|gb|AAH67612.1| LOC407684 protein [Danio rerio]
285.0 [0..2] [176..8]

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Predicted Domain #1
Region A:
Residues: [1-176]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMSFEWPWQ YRFPPFFTLQ PNVDTRQKQL AAWCSLVLSF CRLHKQSSMT VMEAQESPLF  60
   61 NNVKLQRKLP VESIQIVLEE LRKKGNLEWL DKNKSSFLIM WRRPEEWGKL IYQWVSRSGQ 120
  121 NNSVFTLYEL TSGEDTEDEE FHGLDEATLL RALQALQQEH KAEIITVSDG RGVKFF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.221849
Match: 1u5tC
Description: Structure of the ESCRT-II endosomal trafficking complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.77201910025409 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
DNA binding 3.44642410378325 bayes_pls_golite062009
nucleic acid binding 3.38144578566524 bayes_pls_golite062009
transcription factor activity 2.83460075788873 bayes_pls_golite062009
transcription repressor activity 2.39237599101586 bayes_pls_golite062009
sequence-specific DNA binding 2.08341148210578 bayes_pls_golite062009
transcription activator activity 1.98504395280033 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.35380365970626 bayes_pls_golite062009
transferase activity 1.0863867010063 bayes_pls_golite062009
signal transducer activity 0.968719315363638 bayes_pls_golite062009
molecular transducer activity 0.968719315363638 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
transcription factor binding 0.63938506997853 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.42135864069093 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

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