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View Structure Prediction Details

Protein: ING1_MOUSE
Organism: Mus musculus
Length: 279 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ING1_MOUSE.

Description E-value Query
Range
Subject
Range
gi|6456562 - gi|6456562|gb|AAF09183.1|AF149820_1 p33ING1 protein [Mus musculus]
235.0 [0..1] [279..1]
gi|7158365, gi|2... - gi|7158365|gb|AAF37421.1|AF149721_1 ING1 tumor suppressor, variant A [Homo sapiens], gi|5689257|dbj|...
235.0 [0..1] [279..1]
gi|109121284 - gi|109121284|ref|XP_001084274.1| PREDICTED: similar to inhibitor of growth family, member 1 isoform ...
230.0 [0..1] [279..1]
gi|57108731 - gi|57108731|ref|XP_535556.1| PREDICTED: similar to inhibitor of growth family, member 1 [Canis famil...
228.0 [0..1] [279..1]
gi|54289535, gi|... - gi|84370364|ref|NP_001033680.1| inhibitor of growth family, member 1 [Rattus norvegicus], gi|5428953...
224.0 [0..1] [279..1]
gi|118150934, gi... - gi|118150934|ref|NP_001071382.1| inhibitor of growth family, member 1 [Bos taurus], gi|112362114|gb|...
218.0 [0..1] [279..1]
gi|57547050 - gi|57547050|gb|AAW52339.1| p33ING1b variant 5 [Xenopus laevis]
215.0 [0..1] [279..1]

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Predicted Domain #1
Region A:
Residues: [1-188]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSPANGEQI HLVNYVEDYL DSIESLPFDL QRNVSLMREI DAKYQEILKE LDDYYEKFKR  60
   61 ETDGTQKRRV LHCIQRALIR SQELGDEKIQ IVSQMVELVE NRSRQVDSHV ELFEAHQDIS 120
  121 DGTGGSGKAG QDKSKSEAIT QADKPNNKRS RRQRNNENRE NASNNHDHDD ITSGTPKEKK 180
  181 AKTSKKKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [189-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSKAKAEREA SPADLPIDPN EPTYCLCNQV SYGEMIGCDN DECPIEWFHF SCVGLNHKPK  60
   61 GKWYCPKCRG ESEKTMDKAL EKSKKERAYN R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1weuA
Description: Solution structure of PHD domain in ING1-like protein BAC25009
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
histone acetyltransferase activity 4.42006417174691 bayes_pls_golite062009
lysine N-acetyltransferase activity 4.42006417174691 bayes_pls_golite062009
binding 2.93415748500038 bayes_pls_golite062009
transcription regulator activity 2.89424169822343 bayes_pls_golite062009
DNA binding 2.67786232715949 bayes_pls_golite062009
nucleic acid binding 2.6327300364647 bayes_pls_golite062009
protein binding 2.4739446713993 bayes_pls_golite062009
N-acetyltransferase activity 2.45891382338105 bayes_pls_golite062009
2.30943634164867 bayes_pls_golite062009
transcription repressor activity 2.13907615882531 bayes_pls_golite062009
N-acyltransferase activity 2.10269412591001 bayes_pls_golite062009
transcription activator activity 2.06834170490665 bayes_pls_golite062009
acetyltransferase activity 1.67698565960055 bayes_pls_golite062009
transcription factor activity 1.62385700361588 bayes_pls_golite062009
sequence-specific DNA binding 1.17383679324331 bayes_pls_golite062009
0.980773466347219 bayes_pls_golite062009
protein deacetylase activity 0.70947285330787 bayes_pls_golite062009
histone deacetylase activity 0.702105274574553 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.628989167572806 bayes_pls_golite062009
chromatin binding 0.39425178848458 bayes_pls_golite062009
histone binding 0.34407565577548 bayes_pls_golite062009
protein kinase activity 0.147176550674534 bayes_pls_golite062009
transcription factor binding 0.0538806851320555 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle